甲基(4-甲氧基-3-硝基苯基)乙酸酯合成路线 （共 15 条）
反应条件
potassium carbonate T=20°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 106; 107 ;
WO 2013/019682 A1
反应条件
sodium hydroxide; nitric acid; acetic anhydride
反应条件
in N,N-dimethyl-formamide
反应条件
nitric acid; acetic anhydride; acetic acid T=-30 - 20°C; 2 h;
参考文献
DR.REDDY'S LABORATORIES LTD.; SASMAL, Pradip Kumar; VAMSEEKRISHNA, Chintakunta; POTLURI, Vijay; TEHIM, Ashok; GAI, Yonghua; ZHANG, Hang
Patent: WO2013/131408 A1, 2013 ;
Location in patent: Page/Page column 63 ;
反应条件
1: aqueous hydrochloric acid 2: hydrogen chloride View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 277, p. 271,281
反应条件
1: aqueous ethanol 2: aqueous hydrochloric acid 3: hydrogen chloride View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 277, p. 271,281
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 277, p. 271,281
反应条件
1: sulfuric acid / 70 °C / |Reflux 2: potassium carbonate / 20 °C View Scheme
参考文献
WO2013/19682 A1, ;
WO 2013/019682 A1
反应条件
1: acetic acid; nitric acid / 1 h / 0 °C 2: sulfuric acid / 70 °C / |Reflux 3: potassium carbonate / 20 °C View Scheme
参考文献
WO2013/19682 A1, ;
WO 2013/019682 A1
反应条件
in acetonitrile 1 h; Yield given;
参考文献
Chemistry of Natural Compounds, , vol. 26, # 6 p. 691 - 696
Khimiya Prirodnykh Soedinenii, , # 6 p. 811 - 818
