5-溴-2,2′-联噻吩合成路线 （共 42 条）
反应条件
N-bromosuccinmide in chloroform; acetic acid T=20°C; 1 h;
参考文献
Texas Biotechnology Corp.
Patent: US6342610 B2, 2002 ;
Location in patent: Page column 58 ;
US 6342610 B2
反应条件
2-bromo-3,4-dichloropyridazin-3(2H)-one; zinc dibromide in dichloromethane T=20°C; 0.0833333 h; regioselective reaction;
参考文献
Synlett, , # 3 p. 490 - 494
反应条件
1: thien-2-yl bromide With magnesium; iodine in tetrahydrofuran Grignard reaction; 1 h; Heating; 2: 2,5-dibromothiophene With palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene] in tetrahydrofuran; dichloromethane T=0 - 20°C; Arylation; 18 h;
参考文献
Helvetica Chimica Acta, , vol. 82, # 12 p. 2160 - 2171
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran T=80°C; 12 h; Inert atmosphere;
参考文献
Montserrat Martinez; Pena-Lopez, Miguel; Sestelo, Jose Perez; Sarandeses, Luis A.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 19 p. 3892 - 3898
反应条件
in hexane; chloroform; acetic acid
参考文献
Texas Biotechnology Corporation
Patent: US5594021 A1, 1997 ;
US 5594021 A
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether 1.) -30 deg C; 2.) -10 deg C; 3.) RT;
参考文献
Tetrahedron, , vol. 41, # 10 p. 1919 - 1930
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2: With methanol in tetrahydrofuran; hexane T=0°C;
参考文献
Organic Letters, , vol. 10, # 18 p. 3937 - 3940
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -70 deg C, 30 min;
参考文献
Pham, Chiem Van; Burkhardt, A.; Shabana, R.; Cunningham, David D.; Mark, Harry B.; Zimmer, Hans
Phosphorus, Sulfur and Silicon and the Related Elements, 1989 , vol. 46, p. 153 - 168
反应条件
lead(IV) tetraacetate; lithium bromide; lithium iodide in chloroform T=20°C; 0.5 h; regioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 14 p. 2788 - 2791
反应条件
aluminum oxide; bis-triphenylphosphine-palladium(II) chloride; potassium fluoride T=100°C; Suzuki coupling; microwave irradiation; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 67, # 25 p. 8877 - 8884
