6-氟吲哚-2-甲酸乙酯合成路线 （共 10 条）
反应条件
iron; acetic acid in ethanol 3.5 h; Heating / reflux;
参考文献
Sankyo Company, Limited
Patent: EP1764075 A1, 2007 ;
Location in patent: Page/Page column 81-82; 91 ;
反应条件
in hexane T=200°C; Hemetsberger-Knittel synthesis; P=9000.9 - 9750.98 Torr; 0.0833333 h; Microwave irradiationInert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 4 p. 1550 - 1561
反应条件
hydrogenchloride; iron in ethanol; water T=0°C; 5 h; Heating / reflux;
参考文献
US2005/96321 A1, ;
Page/Page column 5 ;
反应条件
copper(I) oxide; caesium carbonate in 1-methyl-pyrrolidin-2-one T=100°C; 16 h; Inert atmosphereSealed tube;
参考文献
Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 511 - 514
反应条件
1: sodium ethanolate / ethanol / -10 - 0 °C / Inert atmosphere 2: hexane / 0.08 h / 200 °C / 9000.9 - 9750.98 Torr / Microwave irradiation; Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 4 p. 1550 - 1561
反应条件
sulfuric acid; acetic acid
参考文献
Journal of the Chemical Society, , p. 1283,1284
反应条件
1: aq.-ethanolic NaOH 2: 250 °C View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: With sodium hydroxide in ethanol 3 h; Reflux; 2: With acetic acid in ethanol; water pH=5; Cooling with ice;
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: 6-fluoro-1H-indole-2-carboxylic acid ethyl ester; methyl 6-fluoroindole-2-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=20°C; 12 h;
参考文献
Burnier, Philippe; Froissant, Jacques; Marabout, Benoit; Marguet, Frank; Puech, Frederic
Patent: US2005/96321 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 6-fluoro-1H-indole-2-carboxylic acid ethyl ester; methyl 6-fluoroindole-2-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=20°C; 12 h;
参考文献
Froissant, Jacques; Marabout, Benoit; Marguet, Frank; Puech, Frederic
Patent: US2005/124615 A1, 2005 ;
Location in patent: Page/Page column 4 ;
