5-氟吲哚-2-甲酸乙酯合成路线 （共 26 条）
反应条件
1: hydrogenchloride; tin(ll) chloride / water / 4 h / |Cooling with ice 2: ethanol / 5 h / |Inert atmosphere; |Reflux 3: polyphosphoric acid / 3 h / 85 °C View Scheme
参考文献
Tetrahedron, , vol. 70, # 3 p. 702 - 707
反应条件
2: H2SO4; acetic acid / Siedetemperatur View Scheme
参考文献
Journal of the Chemical Society, , p. 1283,1284
反应条件
1: With sodium hydroxide in ethanol 3 h; Reflux; 2: With acetic acid in ethanol; water pH=5; Cooling with ice;
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: aq.-ethanolic NaOH 2: 250 °C View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: aq.-ethanolic KOH 2: 250 °C 3: acetic acid View Scheme
参考文献
Quadbeck; Roehm
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954 , vol. 297, p. 229,233
反应条件
iodine; potassium hydroxide in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
Neagoie, Cleopatra; Vedrenne, Emeline; Buron, Frederic; Merour, Jean-Yves; Rosca, Sorin; Bourg, Stephane; Lozach, Olivier; Meijer, Laurent; Baldeyrou, Brigitte; Lansiaux, Amelie; Routier, Sylvain
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 379 - 396
反应条件
trichlorophosphate
T=80 - 100°C; Vilsmeier-Haack formylation; 2 h;
参考文献
El-Gendy, Adel A.; Said, Mohamed M.; Ghareb, Nagat; Mostafa, Yasser M.; El-Ashry, El Sayed H.
Archiv der Pharmazie, 2008 , vol. 341, # 5 p. 294 - 300
反应条件
sodium acetate; trichlorophosphate
Yield given. Multistep reaction;
参考文献
Troschuetz, Reinhard; Hoffmann, Armin
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1431 - 1440
反应条件
potassium carbonate in N,N-dimethyl-formamide
1.5 h; Heating;
参考文献
Hlasta; Luttinger; Perrone; Silbernagel; Ward; Haubrich
Journal of medicinal chemistry, 1987 , vol. 30, # 9 p. 1555 - 1562
反应条件
sodium hydroxide; tetrabutylammomium bromide in diethyl ether
6 h; Ambient temperature;
参考文献
Lehr, Matthias
Journal of Medicinal Chemistry, 1997 , vol. 40, # 17 p. 2694 - 2705
