(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮合成路线 （共 42 条）
反应条件
1: 50 percent / 20percent H2SO4 / acetic acid / 5 h / 80 - 90 °C 2: 79 percent / Na2CO3 / diethyl ether / 2.5 h / Ambient temperature 3: 46 percent / methanol; diethyl ether / 3 h 4: 70 percent / K2CO3 / acetone; H2O / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 46 percent / methanol; diethyl ether / 3 h 2: 70 percent / K2CO3 / acetone; H2O / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 13 p. 2515 - 2521
反应条件
1: 70 percent / K2CO3 / acetone; H2O / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 13 p. 2515 - 2521
反应条件
bovine spleen cathepsin B T=37°C; pH=5; aq. bufferEnzymatic reaction;
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 5 p. 348 - 352
反应条件
1: morpholine; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran 2: bovine spleen cathepsin B / 37 °C / pH 5 / aq. buffer; Enzymatic reaction View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 5 p. 348 - 352
反应条件
1: 85 percent / DMAP / CH2Cl2 / 24 h / 20 - 40 °C 2: 98 percent / MeONa / methanol / 1 h / 0 °C 3: 98 percent / CH2Cl2; trifluoroacetic acid / 5 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 82, # 9 p. 1502 - 1508
反应条件
1: aqueous HCl 2: CH2Cl2; diethyl ether View Scheme
参考文献
Helvetica Chimica Acta, , vol. 37, p. 18,29
Farmaco, Edizione Scientifica, , vol. 10, p. 877,881
参考文献
Journal of Organic Chemistry, , vol. 51, # 13 p. 2515 - 2521
参考文献
Uffer et al.
Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29
反应条件
in methanol Oxidation; 24 h;
参考文献
Danieli, Bruno; Lesma, Giordano; Passarella, Daniele; Prosperi, Davide; Silvani, Alessandra; Bombardelli, Ezio
Helvetica Chimica Acta, 1999 , vol. 82, # 9 p. 1502 - 1508
