(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮合成路线 （共 42 条）
反应条件
trifluoroacetic acid in dichloromethane T=25°C; 3 h;
参考文献
Lagnoux, David; Darbre, Tamis; Schmitz, M. Lienhard; Reymond, Jean-Louis
Chemistry - A European Journal, 2005 , vol. 11, # 13 p. 3941 - 3950
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate; triethylamine in acetonitrile 20 h; Reflux; 2: With sodium methylate in methanol T=0°C; 0.5 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Zhang, Xuan; Zhang, Jie; Tong, Linjiang; Luo, Yu; Su, Mingbo; Zang, Yi; Li, Jia; Lu, Wei; Chen, Yi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 3240 - 3244
反应条件
1: 80 percent / NaOMe / methanol / 0.5 h / 0 °C 2: 100 percent / TFA / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 13 p. 3941 - 3950
反应条件
in diethyl ether; dichloromethane
参考文献
Australian Journal of Chemistry, , vol. 45, # 10 p. 1577 - 1588
反应条件
1: 2,6-lutidine 2: I2; CF3CO2Ag / CHCl3 3: Et2NH; CuI / (Ph3P)2PdCl2 / dimethylsulfoxide 4: TBAF / tetrahydrofuran 5: (COCl)2; DMSO; Et3N 7: (COCl)2; DMSO; Et3N 9: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 10: Ph3P; H2O 11: Et3N 12: 70 percent / 1,2-dichloro-benzene / Heating 13: LiOH 15: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 16: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 17: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: I2; CF3CO2Ag / CHCl3 2: Et2NH; CuI / (Ph3P)2PdCl2 / dimethylsulfoxide 3: TBAF / tetrahydrofuran 4: (COCl)2; DMSO; Et3N 6: (COCl)2; DMSO; Et3N 8: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 9: Ph3P; H2O 10: Et3N 11: 70 percent / 1,2-dichloro-benzene / Heating 12: LiOH 14: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 15: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 16: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: Et2NH; CuI / (Ph3P)2PdCl2 / dimethylsulfoxide 2: TBAF / tetrahydrofuran 3: (COCl)2; DMSO; Et3N 5: (COCl)2; DMSO; Et3N 7: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 8: Ph3P; H2O 9: Et3N 10: 70 percent / 1,2-dichloro-benzene / Heating 11: LiOH 13: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 14: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 15: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
diethyl ether; dichloromethane
参考文献
Journal of the American Chemical Society, , vol. 75, p. 5292
Chemicke Listy, , vol. 46, p. 280,284
Chem.Abstr., , p. 4325
Helvetica Chimica Acta, , vol. 37, p. 18,29
Farmaco, Edizione Scientifica, , vol. 10, p. 877,881
反应条件
2: (COCl)2; DMSO; Et3N 4: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 5: Ph3P; H2O 6: Et3N 7: 70 percent / 1,2-dichloro-benzene / Heating 8: LiOH 10: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 11: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 12: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
反应条件
1: (COCl)2; DMSO; Et3N 3: (COCl)2; DMSO; Et3N 5: 64 percent / PPh3; DEAD; (PhO)2P(O)N3 6: Ph3P; H2O 7: Et3N 8: 70 percent / 1,2-dichloro-benzene / Heating 9: LiOH 11: 45 percent / TMSOTf / various solvent(s) / -78 - -50 °C 12: 62 percent / TMSOTf; Et3N / CH2Cl2 / 0 - 10 °C 13: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2804 - 2805
