4-甲氧基-26-二甲基苯胺合成路线 （共 18 条）
反应条件
1: With tin(ll) chloride in ethanol Heating / reflux; 2: With sodium hydroxide; water
参考文献
JANSSEN PHARMACEUTICA N.V.; ARTS, Frank, Xavier, Jozef, Herwig
Patent: WO2006/15985 A1, 2006 ;
Location in patent: Page/Page column 55-56 ;
反应条件
tris-(2-chloro-ethyl)-amine; sulfuric acid in chloroform T=0°C; 1 h;
参考文献
Sprecher, Milon; Kost, Daniel
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1016 - 1026
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Micksch, Maik; Tenne, Mario; Strassner, Thomas
European Journal of Organic Chemistry, 2013 , # 27 p. 6137 - 6145
反应条件
1: SOCl2 / a) reflux, 30 min, b) RT, 24 h 2: 3 h / Ambient temperature 3: 50 percent / HN3, H2SO4 / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Sprecher, Milon; Kost, Daniel
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1016 - 1026
反应条件
1: 3 h / Ambient temperature 2: 50 percent / HN3, H2SO4 / CHCl3 / 1 h / 0 °C View Scheme
参考文献
Sprecher, Milon; Kost, Daniel
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1016 - 1026
反应条件
1: 4-iodo-2,6-dimethylbenzenamine With copper(l) iodide; 3,4,7,8-tetra-methyl-1,10-phenanthroline; caesium carbonate in toluene T=80°C; 0.333333 h; Inert atmosphere; 2: methanol in toluene T=80°C; 24 h; Inert atmosphere;
参考文献
Lane, Timothy K.; D'Souza, Brendan R.; Louie, Janis
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7555 - 7563
反应条件
palladium 10 on activated carbon; hydrogen in tetrahydrofuran; ethanol P=3750.38 Torr; 5 h;
参考文献
Leuthaeusser, Steffen; Schmidts, Volker; Thiele, Christina M.; Plento, Herbert
Chemistry - A European Journal, 2008 , vol. 14, # 18 p. 5465 - 5481
反应条件
ethanol; nickel P=73550.8 - 80905.8 Torr; Hydrogenation;
参考文献
Loefgren; Tegner
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1802,1805
反应条件
1: aq. NaOH solution 2: Raney nickel; ethanol / 73550.8 - 80905.8 Torr / Hydrogenation View Scheme
参考文献
Saunders; Watson
Biochemical Journal, 1950 , vol. 46, p. 629,633
反应条件
sodium disulfite; sodium carbonate; sodium nitrite; 4-aminobenzenesulfonic acid 1.) water, a.) RT, overnight, b.) 40 deg C, 3 h, 2.) water, 60 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
