2-(溴甲基)四氢-2H-吡喃合成路线 （共 16 条）
反应条件
1.1: Na / diethyl ether / 2 h / Heating 1.2: 87 percent / H2O 2.1: 91 percent / AIBN / 80 °C 3.1: 74 percent / H2; diethylamine / 5 percent Pd/C / ethanol; ethyl acetate / 0.5 h / 9120 Torr View Scheme
参考文献
Tra Anh; Blancou; Commeyras
Journal of Fluorine Chemistry, 1999 , vol. 96, # 2 p. 167 - 174
反应条件
1.1: Na / diethyl ether / 2 h / Heating 1.2: 87 percent / H2O 2.1: 91 percent / AIBN / 80 °C View Scheme
参考文献
Tra Anh; Blancou; Commeyras
Journal of Fluorine Chemistry, 1999 , vol. 96, # 2 p. 167 - 174
反应条件
1: 76 percent / Na 2: 80 percent / PBr3 / dimethylformamide / 24 h / Ambient temperature View Scheme
参考文献
Gribble, Gordon W.; Silva, Richard A.; Saulnier, Mark G.
Synthetic Communications, 1999 , vol. 29, # 4 p. 729 - 747
反应条件
potassium carbonate in N,N-dimethyl-formamide T=125°C; 3 h;
参考文献
NOVARTIS AG; IRM LLC; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; GUAGNANO, Vito; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; MCCARTHY, Clive; MICHELLYS, Pierre-Yves; STAUFFER, Frederic; STUTZ, Stefan; VAUPEL, Andrea
Patent: WO2011/29915 A1, 2011 ;
Location in patent: Page/Page column 66 ;
WO 2011/029915 A1
反应条件
tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide
T=80°C; 3 h;
参考文献
Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 27 ;
US 20040087601 A1
反应条件
t-butyl ammonium iodide; sodium iodide in acetone
Heating / reflux;
参考文献
PHARMACOPEIA, INC.
Patent: US2003/229092 A1, 2003 ;
Location in patent: Page 15 ;
