3-氨基-4-环己基氨基苯甲酸乙酯合成路线 （共 7 条）
反应条件
hydrogen; palladium(II) hydroxide/carbon in methanol P=760.051 Torr; 72 h;
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
1: 97 percent / H2SO4 2: K2CO3 / dimethylsulfoxide / 20 °C 3: H2 / Pd/C / ethanol / 760 Torr View Scheme
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
反应条件
1: K2CO3 / dimethylsulfoxide / 20 °C 2: H2 / Pd/C / ethanol / 760 Torr View Scheme
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
反应条件
1: 98 percent / dimethylsulfoxide / 6 h / 70 °C 2: 99 percent / H2 / 20 percent Pd(OH)2/C / methanol / 24 h / 760 Torr View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
反应条件
1: 98 percent / dimethylsulfoxide / 6 h / 70 °C 2: 99 percent / H2 / 20 percent Pd(OH)2/C / methanol / 24 h / 760 Torr View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
反应条件
sodium dithionite in ethanol T=90°C; 3 h; Inert atmosphere;
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
反应条件
1: aq. oxone / dimethylformamide / 4 h / 20 °C
2: 62.07 g / aq. NaOH / methanol; dimethylformamide / 2 h / 60 °C
View Scheme
参考文献
Beaulieu, Pierre L.; Bousquet, Yves; Gauthier, Jean; Gillard, James; Marquis, Martin; McKercher, Ginette; Pellerin, Charles; Valois, Serge; Kukolj, George
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6884 - 6892
