6-氨基-3,4-二氢-1(2H)-萘酮合成路线 （共 32 条）
反应条件
1: With α-bromo-α,α-dimethylacetamide; sodium hydroxide in N,N-dimethyl acetamide T=20°C; 5 h; 2: With sodium hydroxide in N,N-dimethyl acetamide T=50°C; 1 h;
参考文献
Cui, Li-Qian; Dong, Zhi-Lei; Liu, Kai; Zhang, Chi
Organic Letters, 2011 , vol. 13, # 24 p. 6488 - 6491
反应条件
sulfuric acid T=90°C;
参考文献
Harris III, Ralph N.; Stabler, Russel S.; Repke, David B.; Kress, James M.; Walker, Keith A.; Martin, Renee S.; Brothers, Julie M.; Ilnicka, Mariola; Lee, Simon W.; Mirzadegan, Tara
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3436 - 3440
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Lim, Ju-Ok; Jin, Mi-Kyoung; Ryu, HyungChul; Kang, Dong Wook; Lee, Jeewoo; Pearce, Larry V.; Tran, Richard; Toth, Attila; Blumberg, Peter M.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 322 - 331
反应条件
sodium hydroxide; water in N,N-dimethyl acetamide 1 h; Heating;
参考文献
Mizuno, Masahiro; Yamano, Mitsuhisa
Organic Letters, 2005 , vol. 7, # 17 p. 3629 - 3631
反应条件
1: 5.60 g / sodium hydroxide / N,N-dimethyl-acetamide / 3 h / 50 °C 2: 287 mg / sodium hydroxide; water / N,N-dimethyl-acetamide / 1 h / Heating View Scheme
参考文献
Organic Letters, , vol. 7, # 17 p. 3629 - 3631
反应条件
(i) CrO3, aq. AcOH, Ac2O, (ii) aq. HCl; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 27, p. 70 - 76
反应条件
1: 95.5 percent / aqueous hydrobromic acid / 8 h / Heating 2: sodium hydroxide / N,N-dimethyl-acetamide / 1.5 h / 20 °C 3: sodium hydroxide / N,N-dimethyl-acetamide / 3.5 h / 100 °C 4: 262 mg / sodium hydroxide; water / N,N-dimethyl-acetamide / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 17 p. 3629 - 3631
反应条件
1: 62 percent / NaNO2, CuSO4 / H2O; aq. HCl / 2 h / 0 °C 2: 38 percent / KOH / ethanol; H2O / 4 h / Heating View Scheme
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
反应条件
potassium iodide; sodium nitrite
参考文献
Harris III, Ralph N.; Stabler, Russel S.; Repke, David B.; Kress, James M.; Walker, Keith A.; Martin, Renee S.; Brothers, Julie M.; Ilnicka, Mariola; Lee, Simon W.; Mirzadegan, Tara
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3436 - 3440
反应条件
(i) NaNO2, aq. HCl, (ii) aq. H2SO4; Multistep reaction;
参考文献
Allinger,N.L.; Jones,E.S.
Journal of Organic Chemistry, 1962 , vol. 27, p. 70 - 76
