1-甲氧基羰基-beta-咔啉合成路线 （共 11 条）
反应条件
manganese(IV) oxide in 1,4-dioxane T=20°C; Inert atmosphereRefluxMolecular sieve;
参考文献
Baiget, Jessica; Llona-Minguez, Sabin; MacKay, Simon P.; Sutcliffe, Oliver B.; Lang, Stuart; Suckling, Colin J.
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, art. no. 164, p. 1407 - 1411
反应条件
potassium permanganate in acetone
参考文献
Ohmoto, Taichi; Koike, Kazuo
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3579 - 3583
反应条件
1: 94 percent / hydrogen chloride; molecular sieves 3 Angstroem / 3 h / Heating 2: 87 percent / sulfur; 2,2,6,6-tetramethylpiperidine / xylene / 5 h / Heating View Scheme
参考文献
Xin, Botao; Tang, Weifang; Wang, Yue; Lin, Guowu; Liu, Haichun; Jiao, Yu; Zhu, Yong; Yuan, Haoliang; Chen, Yadong; Lu, Tao
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4783 - 4786
反应条件
potassium permanganate in acetone
参考文献
Ohmoto, Taichi; Koike, Kazuo
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3579 - 3583
反应条件
1: 80 percent / potassium hydroxide; glacial acetic acid / H2O / 2 h / 20 °C / pH 4.0 2: 94 percent / hydrogen chloride; molecular sieves 3 Angstroem / 3 h / Heating 3: 87 percent / sulfur; 2,2,6,6-tetramethylpiperidine / xylene / 5 h / Heating View Scheme
参考文献
Panosyan; Still
Canadian Journal of Chemistry, 2001 , vol. 79, # 7 p. 1110 - 1114
反应条件
1: hydrogenchloride; potassium hydroxide / water / 20 °C / pH 4 2: thionyl chloride / 6 h / Reflux 3: potassium permanganate / N,N-dimethyl-formamide / 24 h / 20 °C View Scheme
参考文献
Xin, Botao; Tang, Weifang; Wang, Yue; Lin, Guowu; Liu, Haichun; Jiao, Yu; Zhu, Yong; Yuan, Haoliang; Chen, Yadong; Lu, Tao
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4783 - 4786
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Ohmoto, Taichi; Koike, Kazuo
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3579 - 3583
反应条件
1.1: 85 percent / DIBALH / CH2Cl2 / 0.08 h / -40 °C 2.1: HMDS; n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: tetrahydrofuran; hexane / 0.17 h / -78 °C 2.3: 83 percent / EtOH / tetrahydrofuran; hexane / 0.5 h / 20 °C View Scheme
参考文献
Suzuki, Hideharu; Adachi, Makoto; Ebihara, Yuki; Gyoutoku, Hiroshi; Furuya, Hinako; Murakami, Yasuoki; Okuno, Hiroaki
Synthesis, 2005 , # 1 art. no. F09504SS, p. 28 - 32
参考文献
Nippon Shinyaku Co. Ltd.
Patent: US4241064 A1, 1980 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 5 h; Ambient temperature;
参考文献
Ohmoto, Taichi; Koike, Kazuo
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3579 - 3583
