(8S,9S,10R,13R,14S,17R)-10,13-二甲基-17-[(2R)-6-甲基庚烷-2-基]-8,9,11,12,14,15,16,17-八氢环戊烯并[a]菲-3-酮合成路线 （共 4 条）
3464-60-6(8S,9S,10R,13R,14S,17R)-10,13-二甲基-17-[(2R)-6-甲基庚烷-2-基]-8,9,11,12,14,15,16,17-八氢环戊烯并[a]菲-3-酮
→
反应条件
(Ph)2SiH2; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) in chloroform 1 h; Ambient temperature;
参考文献
Keinan, Ehud; Greenspoon, Noam
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7314 - 7325
3464-60-6(8S,9S,10R,13R,14S,17R)-10,13-二甲基-17-[(2R)-6-甲基庚烷-2-基]-8,9,11,12,14,15,16,17-八氢环戊烯并[a]菲-3-酮
→
反应条件
1: 75 percent / p-TsOH / butyl acetate / 8 h / Heating 2: 94 percent / Ca(BH4)2 / diethyl ether; methanol; ethanol / 3 h / -10 °C 3: 45 percent / H2 / (Ph3P)3RhCl / toluene / 2 h / Ambient temperature View Scheme
参考文献
Dolle, Frederic; Kappler, Christine; Hetru, Charles; Rousseau, Bernard; Coppo, Michele; et al.
Tetrahedron, 1990 , vol. 46, # 15 p. 5305 - 5316
3464-60-6(8S,9S,10R,13R,14S,17R)-10,13-二甲基-17-[(2R)-6-甲基庚烷-2-基]-8,9,11,12,14,15,16,17-八氢环戊烯并[a]菲-3-酮+
→
参考文献
Diss. <Danzig 1940> S. 8, 17
3464-60-6(8S,9S,10R,13R,14S,17R)-10,13-二甲基-17-[(2R)-6-甲基庚烷-2-基]-8,9,11,12,14,15,16,17-八氢环戊烯并[a]菲-3-酮
→
反应条件
1: toluene-4-sulfonic acid 2: palladium/BaSO4; ethyl acetate / Hydrogenation.Behandeln des Reaktionsprodukts mit methanol. KOH View Scheme
参考文献
Cambie,R.C. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 1240 - 1245
