2-(羟基甲基)喹唑啉-4(3H-)-酮合成路线 （共 10 条）
反应条件
hydrogen bromide in water
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
potassium hydroxide T=80°C; 1 h;
参考文献
Bergman, Jan; Brynolf, Anna
Tetrahedron, 1990 , vol. 46, # 4 p. 1295 - 1310
反应条件
1: 67 percent / urea hydrogen peroxide; K2CO3 / acetone; H2O / 50 h / 82 °C 2: 61 percent / aq. HBr, 48 percent / 11 h / Heating View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: 74 percent / Py / dimethylformamide / 24 h / 20 °C 2: 67 percent / urea hydrogen peroxide; K2CO3 / acetone; H2O / 50 h / 82 °C 3: 61 percent / aq. HBr, 48 percent / 11 h / Heating View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: 75 percent / dioxane / 1 h / Ambient temperature 2: 81 percent / 2 M aq. KOH / 1 h / 80 °C View Scheme
参考文献
Bergman, Jan; Brynolf, Anna
Tetrahedron, 1990 , vol. 46, # 4 p. 1295 - 1310
反应条件
sodium hydroxide in water 1 h; RefluxInert atmosphere;
参考文献
Li, Hong-Ze; He, Hai-Yun; Han, Yuan-Yuan; Gu, Xin; He, Lin; Qi, Qing-Rong; Zhao, Ying-Lan; Yang, Li
Molecules, 2010 , vol. 15, # 12 p. 9473 - 9485
反应条件
1.1: sodium / methanol / 0.67 h / 25 °C / Inert atmosphere 1.2: 2 h / 25 °C / Inert atmosphere 2.1: sodium hydroxide / water / 1 h / Reflux; Inert atmosphere View Scheme
参考文献
Li, Hong-Ze; He, Hai-Yun; Han, Yuan-Yuan; Gu, Xin; He, Lin; Qi, Qing-Rong; Zhao, Ying-Lan; Yang, Li
Molecules, 2010 , vol. 15, # 12 p. 9473 - 9485
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0 - 20°C; 22 h;
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C 2: water; N,N-dimethyl-formamide / 4 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
2: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
3: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
