1: With selenium(IV) oxide; dihydrogen peroxide in dichloromethane; water T=20°C; Baeyer-Villiger Oxidation; 24 h; 2: With lithium hydroxide in 1,4-dioxane
T=37°C; in vitro methabolism; Vmax (maximal velocity of metabolism) and Km (Michaelis constant) for ring hydroxylation and N-deethylation in microsomal incubation mixture (pH 7.4);
参考文献
Journal of Pharmaceutical Sciences, , vol. 74, # 11 p. 1219 - 1224