3-(苯基甲基)戊烷-3-醇合成路线 （共 29 条）
反应条件
1: methanesulfonic acid / CH2Cl2 / 4 h / -20 - 0 °C 2: CH2Cl2 / 18.5 h / -20 - 18 °C View Scheme
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
in dichloromethane T=-20 - 18°C; Grignard reaction; 18.5 h;
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
1: Et3N / CH2Cl2 / 2 h / 20 °C 2: 30 percent / Li; naphthalene / tetrahydrofuran / 5 h / -78 °C View Scheme
参考文献
Alonso, Emma; Guijarro, David; Martinez, Pedro; Ramon, Diego J.; Yus, Miguel
Tetrahedron, 1999 , vol. 55, # 36 p. 11027 - 11038
反应条件
n-Bu(Ph)Cu(CN)Li2 in tetrahydrofuran T=0°C; 2 h; other reagents; Product distribution;
参考文献
Lipshutz, Bruce H.; Wilhelm, Robert S.; Kozlowski, Joseph A.; Parker, David
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 3928 - 3938
反应条件
naphthalene; lithium 1) THF, -78 deg C, 30 min, 2) THF, -78 to 20 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Guijarro, D.; Mancheno, B.; Yus, M.
Tetrahedron, 1992 , vol. 48, # 22 p. 4593 - 4600
反应条件
thionyl chloride; lithium; ethylene dibromide 2) THF, -78 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Katritzky, Alan R.; Qi, Ming
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4116 - 4120
参考文献
Klages; Haehn
Chemische Berichte, 1904 , vol. 37, p. 1724
参考文献
Konowalow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1904 , vol. 36, p. 228
Chem. Zentralbl., 1904 , vol. 75, # I p. 1496
反应条件
sulfuric acid in benzene
T=75 - 78°C; Yield given;
参考文献
Shklyaev, V. S.; Aleksandrov, B. B.; Legotkina, G. I.; Vakhrin, M. I.; Gavrilov, M. S.; Mikhailovskii, A. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1242
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1560
