4-氟-4'-甲氧基二苯甲酮合成路线 （共 26 条）
反应条件
1: 1-bromo-4-methoxy-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: 4-fluorobenzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 3 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 3 h;
参考文献
Rao, Maddali L.N.; Venkatesh, Varadhachari; Banerjee, Debasis
Tetrahedron, 2007 , vol. 63, # 52 p. 12917 - 12926
反应条件
hydrogenchloride; aluminium trichloride in dichloromethane; water; methoxybenzene
反应条件
aluminium trichloride in carbon disulfide 1 h; Ambient temperature;
参考文献
Shani; Gazit; Livshitz; Biran
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1504 - 1511
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Suzuki, Yukimitsu; Hiraoka, Shuichi; Yokoyama, Akihiro; Yokozawa, Tsutomu
Macromolecules, 2003 , vol. 36, # 13 p. 4756 - 4765
反应条件
tetrabutyl ammonium fluoride in dimethyl sulfoxide T=20°C; 0.5 h;
参考文献
Angewandte Chemie - International Edition, , vol. 45, # 17 p. 2720 - 2725
反应条件
3,3-dimethyl-butan-2-one; [Ru(CO)3Cl2]2; K3PO4*3H2O; [(t-Bu)3PH]BF4 in water; toluene T=100°C; 24 h; Inert atmosphere;
参考文献
Li, Hong; Xu, Yuan; Shi, Erbo; Wei, Wei; Suo, Xiangqiang; Wan, Xiaobing
Chemical Communications, 2011 , vol. 47, # 27 p. 7880 - 7882
反应条件
sodium hydroxide; Rh(1,3-dimesityl-tetrahydropyrimidin-2-ylidene)(COD)(CF3COO) in ethylene glycol dimethyl ether; water T=80°C; 5 h; Product distribution; Further Variations:Catalysts;
参考文献
Imlinger, Nicolas; Mayr, Monika; Wang, Dongren; Wurst, Klaus; Buchmeiser, Michael R.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1836 - 1843
反应条件
anhydrous iron chloride; potassium acetate; sodium hydrogencarbonate; iron(II) chloride T=100°C; Suzuki Coupling; P=760.051 Torr; 6 h; Schlenk technique;
参考文献
Zhong, Yanzhen; Han, Wei
Chemical Communications, 2014 , vol. 50, # 29 p. 3874 - 3877
反应条件
hydrogen fluoride in benzene 1.) RT, 0.5 h, 2.) 50 deg C, 10 min;
参考文献
Shani; Gazit; Livshitz; Biran
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1504 - 1511
