bei laengerer Einw.;

bei der Destillation;

1: With iodine; hypophosphorous acid Heating; 2: With sodium hydroxide in water pH=> 10; 3: With hydrogenchloride in toluene

thionyl chloride in chloroform

T=170 - 180°C; im Einschlussrohr;

bei der Destillation;

thionyl chloride; palladium on barium sulfate; hydrogen; sodium acetate 1.) CHCl3, reflux, 3 h, 2.) AcOH; Yield given. Multistep reaction;

1: sodium hydrogencarbonate / water / 12 h / 20 °C 2: Raney Ni / isopropyl alcohol / 50 - 55 °C / |Autoclave 3: hydrogenchloride / ethyl acetate / 20 h / 0 - 20 °C / |Large scale 4: 5 palladium on charcoal; hydrogen / 6 h / 55 °C / 3878.71 - 4137.29 Torr View Scheme

1.1: sodium hydrogencarbonate / water / 12 h / 20 °C 2.1: Raney Ni / isopropyl alcohol / 50 - 55 °C / |Autoclave 3.1: hydrogenchloride / ethyl acetate / 20 h / 0 - 20 °C / |Large scale 4.1: potassium carbonate / water / 0.5 h / 20 °C / |Large scale 4.2: 10 h / 70 - 75 °C / |Large scale 4.3: 10 h / 5 - 30 °C / |Large scale View Scheme