3-羟基-2-甲基-4(1H)-喹啉酮合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=200°C; 0.5 h; Inert atmosphereMicrowave irradiationMicrowave vial;
参考文献
Hodgkinson, James T.; Galloway, Warren R. J. D.; Saraf, Shreya; Baxendale, Ian R.; Ley, Steven V.; Ladlow, Mark; Welch, Martin; Spring, David R.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 57 - 61
反应条件
1-methyl-pyrrolidin-2-one 0.166667 h; Heating;
参考文献
Hradil, Pavel; Hlavac, Jan; Lemr, Karel
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 141 - 144
反应条件
1: 1.) K2CO3 / 1.) DMF, 90 deg C, 1 h, 2.) DMF, a) from 25 deg C to 32 deg C, 30 min, b) 50 deg C, 30 min 2: 72 percent / N-methylpyrrolidone / 0.17 h / Heating View Scheme
参考文献
Hradil, Pavel; Hlavac, Jan; Lemr, Karel
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 141 - 144
反应条件
hydrogenchloride; potassium hydroxide; dipotassium peroxodisulfate 1.) water, RT, overnight, 2.) reflux, 1 h; Yield given. Multistep reaction;
参考文献
Behrman, Edward J.; Kiser, R. Lee; Garas, Wael F.; Behrman, Elizabeth C.; Pitt, Burnett M.
Journal of Chemical Research, Miniprint, 1995 , # 5 p. 1051 - 1063
反应条件
C30H23FeN2O6; oxygen in N,N-dimethyl-formamide T=100°C; 15 h; Activation energyKineticsMechanismThermodynamic data; chemoselective reaction;
参考文献
Journal of Inorganic Biochemistry, , vol. 108, p. 15 - 21
反应条件
3-hydroxy-2-methyl-4(1H)-quinolone 2,4-dioxygenase (Hod) T=30°C; pH=8; aq. bufferEnzymatic reaction; Kinetics;
参考文献
Chemistry and Biology, , vol. 16, # 12 p. 1259 - 1267
