3-(4-氟苯基)戊二酸合成路线 （共 15 条）
反应条件
1: With sodium hydroxide in methanol; water T=20°C; 12 h; 2: With hydrogenchloride in water T=0°C; 12 h; Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1411052 A1, 2004 ;
Location in patent: Page 53-54 ;
反应条件
piperidine; potassium hydroxide 1.) RT, 3 days, 2.) water, 80 deg C - 85 deg C, 2 h; Yield given. Multistep reaction;
参考文献
UNIVERSITAET DES SAARLANDES
Patent: US2012/46307 A1, 2012 ;
Location in patent: Page/Page column 34 ;
反应条件
potassium hydroxide in ethanol Heating;
参考文献
Ito, Masato; Sakaguchi, Ayaka; Kobayashi, Chika; Ikariya, Takao
Journal of the American Chemical Society, 2007 , vol. 129, # 2 p. 290 - 291
反应条件
1: 4-fluorobenzaldehyde; diethyl malonate With piperidine in toluene 2.5 h; Reflux; 2: diethyl malonate With sodium ethanolate in ethanol T=0°C; 0.25 h; 3: With hydrogenchloride in ethanol; water 8 h; Reflux;
参考文献
Huang, Xiaojun; Zhu, Jiang; Broadbent, Scott
Tetrahedron Letters, 2010 , vol. 51, # 12 p. 1554 - 1557
反应条件
1: KF / ethanol 2: aq. NaOH View Scheme
参考文献
Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950
反应条件
potassium hydroxide in water T=80°C; 3 h;
参考文献
Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950
反应条件
1.1: sodium methylate / methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere 1.2: 72 h / 0 - 20 °C / |Inert atmosphere 2.1: potassium hydroxide / ethanol; water / |Reflux; |Inert atmosphere 3.1: sulfuric acid / water / 6 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Chaubey, Narendra R.; Ghosh, Sunil K.
Tetrahedron: Asymmetry, 2012 , vol. 23, # 15-16 p. 1206 - 1212,7
Title/Abstract Full Text Show Details
Chaubey, Narendra R.; Ghosh, Sunil K.
Tetrahedron Asymmetry, 2012 , vol. 23, # 15-16 p. 1206 - 1212
反应条件
1: potassium hydroxide / ethanol; water / |Reflux; |Inert atmosphere 2: sulfuric acid / water / 6 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Chaubey, Narendra R.; Ghosh, Sunil K.
Tetrahedron: Asymmetry, 2012 , vol. 23, # 15-16 p. 1206 - 1212,7
Title/Abstract Full Text Show Details
Chaubey, Narendra R.; Ghosh, Sunil K.
Tetrahedron Asymmetry, 2012 , vol. 23, # 15-16 p. 1206 - 1212
反应条件
esterase PE8 from Pelagibacterium halotolerans B2T in 1,4-dioxane; aq. phosphate buffer T=30°C; pH=8; 36 h; Enzymatic reaction; TemperaturepH-valueConcentrationSolvent; enantioselective reaction;
参考文献
Wei, Xiaolian; Jiang, Xiawei; Ye, Lidan; Yuan, Shenfeng; Chen, Zhirong; Wu, Min; Yu, Hongwei
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 270 - 277
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0 °C 2: hydrogenchloride; water / |Reflux View Scheme
参考文献
Yang, Hong-Jun; Xiong, Fang-Jun; Li, Jie; Chen, Fen-Er
Chinese Chemical Letters, 2013 , vol. 24, # 7 p. 553 - 558
