(2S)-2-[(1R,4E,7aR)-4-{[(6S)-6-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-2,2-二氧代-1,3,4,5,6,7-六氢-2-苯并噻吩-1-基]亚甲基}-7A-甲基八氢-1H-茚-1-基]-1-丙醇合成路线 （共 3 条）
反应条件
1: 71 percent / I2, PPh3, imidazole / CH2Cl2 / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h 2: 92.5 percent / NaHCO3 / ethanol / 2 h / Heating 3: 73 percent / Zn, NiCl2*6H2O / pyridine / 1.) 60 deg C, 30 min, 2.) 20 deg C, 2.0 h View Scheme
参考文献
Manchand, Percy S.; Yinnikouros, George P.; Belica, Peter S.; Madan, Pradeep
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6574 - 6581
反应条件
Multi-step reaction with 2 steps 1: 71 percent / I2, PPh3, imidazole / CH2Cl2 / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h2: 92.5 percent / NaHCO3 / ethanol / 2 h / Heating
参考文献
Manchand, Percy S.; Yinnikouros, George P.; Belica, Peter S.; Madan, Pradeep Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6574 - 6581
反应条件
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 5 - 20 °C / |Inert atmosphere2: sodium acetate; acetic acid; ozone / methanol; dichloromethane / -25 °C / |Inert atmosphere3: sodium tetrahydroborate / methanol; dichloromethane / 2.5 h / -25 - 20 °C / |Inert atmosphere
参考文献
Coutts, Lisa D.; Geiss, William B.; Gregg, Brian T.; Helle, Mark A.; King, Chi-Hsin R.; Itov, Zinovy; Mateo, Mary E.; Meckler, Harold; Zettler, Mark W.; Knutson, Joyce C. Organic Process Research and Development, 2002 , vol. 6, # 3 p. 246 - 255
