2,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯合成路线 （共 12 条）
89373-67-14,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一酰氯
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=0 - 20°C;
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1.1: 88 percent / Et3N / tetrahydrofuran / 10 h / Heating 2.1: 93 percent / LiBr / acetone / 7 h / Heating 3.1: Mg; I2 / tetrahydrofuran / 4 h / Heating 3.2: tetrahydrofuran / -6 - 24 °C 4.1: 84 percent / PCl5 / diethyl ether / 4 h / Heating 5.1: 91 percent / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Angewandte Chemie - International Edition, 2001 , vol. 40, # 13 p. 2492 - 2494
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1.1: Mg; I2 / tetrahydrofuran / 4 h / Heating 1.2: tetrahydrofuran / -6 - 24 °C 2.1: 84 percent / PCl5 / diethyl ether / 4 h / Heating 3.1: 91 percent / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Angewandte Chemie - International Edition, 2001 , vol. 40, # 13 p. 2492 - 2494
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1.1: 93 percent / LiBr / acetone / 7 h / Heating 2.1: Mg; I2 / tetrahydrofuran / 4 h / Heating 2.2: tetrahydrofuran / -6 - 24 °C 3.1: 84 percent / PCl5 / diethyl ether / 4 h / Heating 4.1: 91 percent / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Angewandte Chemie - International Edition, 2001 , vol. 40, # 13 p. 2492 - 2494
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
sulfuric acid 6 h; Heating;
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1: 84 percent / PCl5 / diethyl ether / 4 h / Heating 2: 91 percent / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1: 7.35 g / LiOH / tetrahydrofuran; H2O / 3 h / Heating 2: H2SO4 / Heating View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
sulfuric acid Heating;
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
→
反应条件
1: With lipase B from Candida antarctica in acetonitrile T=20°C; 19 h; 2: With lithium hydroxide in tetrahydrofuran; water 3 h; Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 13 p. 2492 - 2494
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
→
反应条件
1: With lipase B from Candida antarctica in acetonitrile T=20°C; 19 h; 2: With lithium hydroxide in tetrahydrofuran; water 3 h; Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 13 p. 2492 - 2494
