1: C10H8BN3O2 With sodium hydrogencarbonate in ethylene glycol dimethyl ether; water T=45°C; 0.25 h; 2: thien-2-yl bromide With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki cross-coupling reaction; 6 h; Heating; Further stages.;
1: C10H8BN3O2 With sodium hydrogencarbonate in ethylene glycol dimethyl ether; water T=45°C; 0.25 h; 2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki cross-coupling reaction; 6 h; Heating; Further stages.;
1: C10H8BN3O2 With sodium hydrogencarbonate in ethylene glycol dimethyl ether; water T=45°C; 0.25 h; 2: 3-bromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki cross-coupling reaction; 6 h; Heating; Further stages.;
bromine; lithium diisopropyl amide 1.) -20 deg C, 1 h, ether; 2.) from -20 deg C to room temp., ether; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Abarca, Belen; Ballesteros, Rafael; Mojarred, Fatemeh; Jones, Gurnos; Mouat, Deborah J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1865 - 1868
