3-(氯羰基)苯甲酸甲酯合成路线 （共 16 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene T=92°C; 0.833333 h;
参考文献
Murakami, Yasushi; Hara, Hirokazu; Okada, Tetsuo; Hashizume, Hiroshi; Kii, Makoto; Ishihara, Yasunobu; Ishikawa, Michio; Shimamura, Mayumi; Mihara, Shin-Inchi; Kato, Goro; Hanasaki, Kohji; Hagishita, Sanji; Fujimoto, Masafumi
Journal of Medicinal Chemistry, 1999 , vol. 42, # 14 p. 2621 - 2632
反应条件
Pd0(tris(tert-butyl)phosphine)2; (benzyl)-triphenylphosphonium chloride in toluene T=110°C; P=38002.6 Torr; 24 h; GloveboxAutoclaveInert atmosphere;
参考文献
Quesnel, Jeffrey S.; Arndtsen, Bruce A.
Journal of the American Chemical Society, 2013 , vol. 135, # 45 p. 16841 - 16844
反应条件
1: NaOH / methanol / 20 °C 2: SOCl2 / toluene / 1 h / 90 - 95 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 126, # 6 p. 1830 - 1835
反应条件
in chloroform; N,N-dimethyl-formamide
反应条件
1: 42 percent / conc. H2SO4 / tetrahydrofuran / 65 °C 2: SOCl2; DMF / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4188 - 4201
反应条件
2: (saponification) View Scheme
参考文献
Bystrov,V.F. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1968 , vol. 38, p. 1001 - 1005,963 - 966
反应条件
2: (saponification) View Scheme
参考文献
Bystrov,V.F. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1968 , vol. 38, p. 1001 - 1005,963 - 966
反应条件
aluminium trichloride T=45 - 50°C; spaeter bei 80grad, und Verseifung des entstandenen Methylesters mit alkoh. Kalilauge;
参考文献
Smith
Journal of the American Chemical Society, 1921 , vol. 43, p. 1920
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Braun, Hannes A.; Zall, Andrea; Brockhaus, Manfred; Schuetz, Marco; Meusinger, Reinhard; Schmidt, Boris
Tetrahedron Letters, 2007 , vol. 48, # 45 p. 7990 - 7993
反应条件
1: triethylamine / dichloromethane / 2 h 2: tetrahydrofuran / 1 h / -78 - 20 °C 3: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
WO 2011/117254 A1
