2-(三氟甲基)苯甲酸甲酯合成路线 （共 16 条）
反应条件
1: methanol With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-dimethyl-1H-1,2,4-triazol-4-ium iodide in tetrahydrofuran 0.0833333 h; Inert atmosphere; 2: α,α,α-trifluoro-o-tolualdehyde With 3,3',5,5'-tetra-tert-butyl-4,4'-diphenoquinone in tetrahydrofuran T=20°C; 2 h; Inert atmosphere;
参考文献
De Sarkar, Suman; Grimme, Stefan; Studer, Armido
Journal of the American Chemical Society, 2010 , vol. 132, p. 1190 - 1191
反应条件
methanol; 1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 18 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340
反应条件
1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 18 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340
反应条件
copper(l) iodide; 1,10-phenanthroline in dimethyl sulfoxide T=60°C; 16 h; Inert atmosphere;
参考文献
Knauber, Thomas; Arikan, Fatih; Roeschenthaler, Gerd-Volker; Goossen, Lukas J.
Chemistry - A European Journal, 2011 , vol. 17, # 9 p. 2689 - 2697
反应条件
triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide T=23 - 50°C; 48 h; Inert atmosphere;
参考文献
Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146
反应条件
copper diacetate; acetic anhydride in N,N-dimethyl-formamide; acetonitrile T=130°C; 1 h; Sealed tube;
参考文献
Jiang, Yuyu; Pan, Shulei; Zhang, Yanghui; Yu, Jingxun; Liu, Hongqiang
European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2027 - 2031
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; 16 h; Inert atmosphereGreen chemistry;
参考文献
Ji, Yuan; Sweeney, Jessica; Zoglio, Jillian; Gorin, David J.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11606 - 11611
反应条件
sulfuric acid T=20°C; 12 h; Inert atmosphere;
参考文献
Skoumbourdis, Amanda P.; LeClair, Christopher A.; Stefan, Eduard; Turjanski, Adrian G.; Maguire, William; Titus, Steven A.; Huang, Ruili; Auld, Douglas S.; Inglese, James; Austin, Christopher P.; Michnick, Stephen W.; Xia, Menghang; Thomas, Craig J.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3686 - 3692
反应条件
copper in N,N-dimethyl acetamide T=100°C; 8 h;
参考文献
Clark, James H.; McClinton, Martin A.; Blade, Robert J.
Journal of the Chemical Society, Chemical Communications, 1988 , # 10 p. 638 - 639
反应条件
isobutyramide; copper T=100°C; 8 h;
参考文献
Journal of Fluorine Chemistry, , vol. 50, # 3 p. 411 - 426
