bromine; acetic acid

water; bromine

1: sulfuric acid / 2 h / 170 - 180 °C 2: water; bromine / 2 h / 25 °C View Scheme

暂无反应条件数据

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere; |Large scale 1.2: 1.58 h / 10 - 20 °C / |Inert atmosphere; |Large scale 2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / 5 h / |Reflux; |Large scale View Scheme

1: 98 percent / i-pentyl nitrite; HOAc / 0 - 5 °C 2: 95 percent / aq. NaOH / 0.5 h / 0 - 5 °C 3: 71 percent / aq. HI / acetonitrile / 1.5 h / 60 °C View Scheme

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere; |Large scale 1.2: 1.58 h / 10 - 20 °C / |Inert atmosphere; |Large scale 2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / 4 h / 75 °C / |Inert atmosphere; |Large scale 2.2: 38 h / |Inert atmosphere; |Reflux; |Large scale View Scheme

1: 2,6-dibromo-4-fluorobenzenamine With potassium tert-butylate in tetrahydrofuran T=20°C; 0.25 h; Inert atmosphereLarge scale; 2: allyl bromide in tetrahydrofuran T=10 - 20°C; 1.58333 h; Inert atmosphereLarge scale;

1: (i) NaNO2, aq. HCl, (ii) aq. EtOCS2K, (iii) KOH 2: aq. KOH View Scheme

sulfuric acid; sodium nitrite 1.) H2O, 4 deg C, 2.) -> RT, 0.5 h; Yield given. Multistep reaction;