N-[4-氯-3-(三氟甲基)苯基]脲合成路线 （共 4 条）
反应条件
acetic acid in water T=40 - 45°C; 1 - 2 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
1: t-Bu Brett Phos; palladium diacetate; caesium carbonate / tetrahydrofuran; water / 2 h / 85 °C / Inert atmosphere 2: hydrogenchloride; water / 1 h / 40 °C / Inert atmosphere View Scheme
参考文献
Breitler, Simon; Oldenhuis, Nathan J.; Fors, Brett P.; Buchwald, Stephen L.
Organic Letters, 2011 , vol. 13, # 12 p. 3262 - 3265
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=110 - 120°C; 12 - 18 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
t-Bu Brett Phos; palladium diacetate; caesium carbonate in tetrahydrofuran; water T=75°C; 5 h; Inert atmosphere;
参考文献
Breitler, Simon; Oldenhuis, Nathan J.; Fors, Brett P.; Buchwald, Stephen L.
Organic Letters, 2011 , vol. 13, # 12 p. 3262 - 3265
