3-氨基-2,6-二甲基吡啶合成路线 （共 8 条）
反应条件
triethylsilane; palladium dichloride in ethanol T=20°C; 0.5 h; Inert atmosphere;
参考文献
Mirza-Aghayan, Maryam; Boukherroub, Rabah; Rahimifard, Mahshid; Bolourtchian, Mohammad
Applied Organometallic Chemistry, 2010 , vol. 24, # 6 p. 477 - 480
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Wachi, Kazuyuki; Terada, Atsusuke
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3020 - 3028
参考文献
Journal of the Chemical Society, , vol. 127, p. 1502
反应条件
1: sulfur trioxide; sulfuric acid; potassium nitrate 2: SnCl2; aqueous HCl View Scheme
参考文献
Chemische Berichte, , vol. 72, p. 577,579
反应条件
2: sodium ethylate / 210 °C View Scheme
参考文献
Clayton; Kenyon
Journal of the Chemical Society, 1950 , p. 2952,2955
反应条件
iron; toluene-4-sulfonic acid in acetic acid; toluene
参考文献
SmithKline Beecham p.l.c.; Symphar SA
Patent: US6303784 B1, 2001 ;
反应条件
sulfuric acid Natriumnitrit hergestellten Diazoniumsalz-Loesung mit Wasser;
参考文献
Chemische Berichte, , vol. 72, p. 577,579
Yakugaku Zasshi, , vol. 61, p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr., , p. 2941
反应条件
1: triethylamine / dichloromethane / 2 h
2: acetic anhydride; potassium acetate; acetic acid; isopentyl nitrite / toluene / 2 h / Reflux
3: potassium carbonate; methanol / 0.08 h / Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BETAGERI, Rajashekhar; COOK, Brian, Nicholas; DISALVO, Darren; HARCKEN, Christian; KUZMICH, Daniel; LIU, Pingrong; LORD, John; MAO, Can; RAZAVI, Hossein
Patent: WO2012/87782 A1, 2012 ;
WO 2012/087782 A1
