反应条件
1: 1.) 48-50percent fluoroboric acid, isoamyl nitrite / 1.) ethanol, -10 deg C, 20 min, 2.) a.) hexane, from 0 deg C to RT, b.) reflux, 30 min 2: 66 percent / potassium permanganate / H2O / 3 h / Heating 3: 99 percent / diethyl ether / 1.) 0 deg C, 2.) RT, overnight 4: 70 percent / LAH / diethyl ether / 0.5 h / -78 °C 5: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) methylene chloride, -60 deg C, 20 min, 2.) from -60 deg C to RT View Scheme
参考文献
Kyba, Evan P.; Liu, Shiuh-Tzung; Chockalingam, Kannappan; Reddy, B. Raghava
Journal of Organic Chemistry, 1988 , vol. 53, # 15 p. 3513 - 3521
