1: With n-butyllithium in diethyl ether; hexane T=-78°C; 1 h; 2: With tri-isopropoxy-borane in diethyl ether; hexane T=-78°C; 1 h; 3: With water in diethyl ether; hexane T=-78 - 20°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/20879 A1, 2006 ;
Location in patent: Page/Page column 102 ;
WO 2006/020879 A1
1: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate in water; N,N-dimethyl-formamide T=110°C; 1 h; Microwave irradiation; 2: With hydrogenchloride; water in methanol T=20°C;
