4-羟基-6-氟喹啉-3-甲酸合成路线 （共 10 条）
反应条件
1: 1 h / Heating 2: various solvent(s) / 1 h / Heating 3: aq. NaOH / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6443 - 6450
反应条件
sodium hydroxide in water T=80°C; Hydrolysis; 0.5 h;
参考文献
Heterocycles, , vol. 51, # 10 p. 2377 - 2384
反应条件
1: various solvent(s) / 1 h / Heating 2: aq. NaOH / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6443 - 6450
反应条件
1: 88 percent / tetrahydrofuran; diethyl ether / 20 °C 2: 89 percent / diphenyl ether / 0.5 h / 230 °C 3: 99 percent / NaOH / H2O / 1 h / 60 °C 4: 0.33 h / 180 °C / heating with powdered glass 5: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Heterocycles, , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 99 percent / NaOH / H2O / 1 h / 60 °C 2: 0.33 h / 180 °C / heating with powdered glass 3: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Heterocycles, , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 0.33 h / 180 °C / heating with powdered glass 2: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Heterocycles, , vol. 51, # 10 p. 2377 - 2384
反应条件
1: 89 percent / diphenyl ether / 0.5 h / 230 °C 2: 99 percent / NaOH / H2O / 1 h / 60 °C 3: 0.33 h / 180 °C / heating with powdered glass 4: NaOH / H2O / 0.5 h / 80 °C View Scheme
参考文献
Heterocycles, , vol. 51, # 10 p. 2377 - 2384
反应条件
sodium hydroxide 1 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6443 - 6450
反应条件
diphenylether; biphenyl
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
反应条件
1: diphenyl ether; biphenyl 2: phosphorus (V)-chloride; phosphoryl chloride / 130 °C View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
