(S)-3-氨基哌啶-2-酮盐酸盐合成路线 （共 16 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 9 h;
参考文献
Nippon Kayaku Kabushiki Kaisha; ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
Patent: EP1489088 A1, 2004 ;
Location in patent: Page 18 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 12 h;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 20 p. 2665 - 2668
反应条件
sodium hydrogencarbonate T=20°C; 15 h;
参考文献
Journal of Natural Products, , vol. 67, # 6 p. 999 - 1004
反应条件
thionyl chloride in methanol T=-78 - 20°C;
参考文献
Ishikawa, Minoru; Hiraiwa, Yukiko; Kubota, Dai; Tsushima, Masaki; Watanabe, Takashi; Murakami, Shoichi; Ouchi, Shokichi; Ajito, Keiichi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2131 - 2150
反应条件
1: With thionyl chloride in methanol T=-45°C; 1 h; 2: in methanol T=20°C; 19 h;
参考文献
Kubota, Dai; Ishikawa, Minoru; Ishikawa, Midori; Yahata, Naokazu; Murakami, Shoichi; Fujishima, Kazuyuki; Kitakaze, Masafumi; Ajito, Keiichi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 12 p. 4158 - 4181
反应条件
1: 79 percent / CHCl3; diethyl ether / 0 °C 2: H2 / Pd/C / methanol / 12 h / 20 °C / 760 Torr View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 20 p. 2665 - 2668
反应条件
sodium ethanolate in ethyl acetate
参考文献
US4533661 A1, ;
US 4533661 A
反应条件
hydrogenchloride in methanol T=30 - 35°C;
参考文献
Winter; Graudums; Frankus
1983 , vol. NO. 11, p. 2021 - 2028
反应条件
(R,R)-1,4-dioxaspiro[4.5]decane-based chiral reagent in toluene T=20°C;
参考文献
Urbanczyk-Lipkowska, Zofia; Fukuda, Noriaki; Tanaka, Koichi
Tetrahedron Asymmetry, 2007 , vol. 18, # 10 p. 1254 - 1256
反应条件
1: HCl (g) / 1 h 2: NaOMe / methanol / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4264 - 4269
