(1S,2R)-(+)-反-2-苯基-1-环己醇合成路线 （共 48 条）
反应条件
1: tin(IV) chloride / dichloromethane / -94 °C 2: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 3: silver nitrate / acetone; water / 3 h / |Reflux 4: acetic acid; zinc / 24 h 5: sodium cyanoborohydride / 1 h 6: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 7: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
N-chloro-succinimide; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in tetrahydrofuran T=-74 - 20°C; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 123, # 15 p. 3603 - 3604
反应条件
1: (ip-pybox)RhCl3, ip-pybox, AgBF4 / tetrahydrofuran / 4 h / 0 °C 2: 1.0 N aq. HCl / 24 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 8 p. 1029 - 1034
反应条件
1: CrO3, H2SO4 / acetone 2: (ip-pybox)RhCl3, ip-pybox, AgBF4 / tetrahydrofuran / 4 h / 0 °C 3: 1.0 N aq. HCl / 24 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 8 p. 1029 - 1034
反应条件
1: CuI 2: CrO3, H2SO4 / acetone 3: (ip-pybox)RhCl3, ip-pybox, AgBF4 / tetrahydrofuran / 4 h / 0 °C 4: 1.0 N aq. HCl / 24 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 8 p. 1029 - 1034
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-(2-((dimethylamino)diphenylmethyl)pyrrolidin-1-yl)(4-(pyrrolidin-1-yl)pyridin-3-yl)methanone in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: acetic anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Synlett, , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
1.1: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 2.1: sodium iodide; sodium azide / acetone; water / 24 h / 20 °C 3.1: sodium cyanoborohydride; acetic acid / 1.67 h / |Inert atmosphere 4.1: hydrogen / methanol / 5.5 h / 70 - 75 °C / 30003 Torr / |Autoclave 4.2: 0.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1.1: sodium iodide; sodium azide / acetone; water / 24 h / 20 °C 2.1: sodium cyanoborohydride; acetic acid / 1.67 h / |Inert atmosphere 3.1: hydrogen / methanol / 5.5 h / 70 - 75 °C / 30003 Torr / |Autoclave 3.2: 0.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(diphenyl(1-(4-(pyrrolidin-1-yl)nicotinoyl)pyrrolidin-2-yl)methyl)urea in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: benzoic acid anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Synlett, , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
