9-[4-(叠氮基甲基)-2,2-二甲基-3a,4,6,6a-四氢呋喃并[3,4-d][1,3]二氧杂环戊烯-6-基]嘌呤-6-胺合成路线 （共 14 条）
反应条件
1: With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in 1,4-dioxane T=20°C; 4 h; Inert atmosphere; 2: With sodium azide; 15-crown-5 in 1,4-dioxane T=110°C; 4 h; Inert atmosphere;
参考文献
Swarbrick, Joanna M.; Graeff, Richard; Garnham, Clive; Thomas, Mark P.; Galione, Antony; Potter, Barry V. L.
Chemical Communications, 2014 , vol. 50, # 19 p. 2458 - 2461
反应条件
sodium azide in N,N-dimethyl-formamide T=65 - 68°C; 0.666667 h;
参考文献
INSTITUT PASTEUR; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT CURIE; POCHET, Sylvie; LABESSE, Gilles; GELIN, Muriel; ASSAIRI, Liliane; DUSSURGET, Olivier; PONCET-MONTANGE, Guillaume
Patent: WO2012/90136 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium azide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Ciuffreda, Pierangela; Loseto, Angela; Santaniello, Enzo
Tetrahedron, 2002 , vol. 58, # 29 p. 5767 - 5771
反应条件
sodium azide; 15-crown-5; tetra-(n-butyl)ammonium iodide in 1,4-dioxane Mitsunobu-like reaction; 5 h; Heating;
参考文献
Liu, Fei; Austin, David J
Tetrahedron Letters, 2001 , vol. 42, # 18 p. 3153 - 3154
反应条件
Si2Cl6 in dichloromethane 0.75 h;
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
1: 72.3 percent / LiN3 / dimethylformamide / 2.25 h / 74 - 80 °C 2: 73 percent / Si2Cl6 / CH2Cl2 / 0.75 h View Scheme
参考文献
MacCoss, Malcolm; Ryu, Eung K.; White, Robert S.; Last, Robert L.
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 788 - 794
反应条件
methanol; ammonia 40 h; Ambient temperature;
参考文献
Ceulemans; Vandendriessche; Rozenski; Herdewijn
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 117 - 127
反应条件
1: 93 percent / pyridine / 2 h / 0 °C 2: 80 percent / NaN3 / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Ciuffreda, Pierangela; Loseto, Angela; Santaniello, Enzo
Tetrahedron, 2002 , vol. 58, # 29 p. 5767 - 5771
反应条件
1: Ambient temperature 2: 88 percent / NH3/EtOH / 1.5 h 3: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 4: 66 percent / NH3, MeOH / 40 h / Ambient temperature View Scheme
参考文献
Ceulemans; Vandendriessche; Rozenski; Herdewijn
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 117 - 127
反应条件
1: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 2: 66 percent / NH3, MeOH / 40 h / Ambient temperature View Scheme
参考文献
Ceulemans; Vandendriessche; Rozenski; Herdewijn
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 117 - 127
