2-甲基-6-氧代-1-2,6-二氢-3-羧酸乙酯合成路线 （共 21 条）
反应条件
in N,N-dimethyl-formamide T=165°C; 14 h;
参考文献
Incyte Corporation; Huang, Taisheng; Feng, Hao; Kong, Lingquan; Wang, Anlai; Ye, Hai Fen
Patent: US2013/96144 A1, 2013 ;
Location in patent: Paragraph 0434; 0435 ;
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane 5 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/95159 A1, 2006 ;
Location in patent: Page/Page column 60-61 ;
WO 2006/095159 A1
反应条件
in N,N-dimethyl-formamide T=175°C; 24 h;
参考文献
VERNALIS (R and D) LTD
Patent: WO2009/93012 A1, 2009 ;
Location in patent: Page/Page column 23; 49 ;
WO 2009/093012 A1
反应条件
in ethanol 2 h; Heating;
参考文献
Hirota, Kosaku; Kitade, Yukio; Shimada, Kaoru; Maki, Yoshifumi
Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1512 - 1516
反应条件
hydrogenchloride T=0 - 20°C;
参考文献
Ferlin, Maria Grazia; Di Marco, Valerio B.; Dean, Annalisa
Tetrahedron, 2006 , vol. 62, # 26 p. 6222 - 6227
反应条件
in ethanol 24 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 50, # 9 p. 1512 - 1516
反应条件
1: HCl / CHCl3 2: 30 percent Pd/C View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 8 p. 587 - 594
反应条件
1: ammonia; silica gel / water / 18 h / 20 °C 2: toluene / 36 h / Reflux; Inert atmosphere 3: N,N-dimethyl-formamide / 144 h / Inert atmosphere; Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 4 p. 1538 - 1552
反应条件
hydrogenchloride in diethyl ether
参考文献
Synthetic Communications, , vol. 35, # 23 p. 2993 - 3001
反应条件
1: 29 percent / acetonitrile / 2 h / Heating 2: 85 percent / ethanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 9 p. 1512 - 1516
