jones' reagent in acetone T=0 - 20°C; 8 h;

1.1: 100 percent / hydrogen / [Rh(COD)Cl]2; (S)-(+)-DTBM-SEGPHOS / toluene / 96 h / 30 °C / 45600 Torr 2.1: HCl / tetrahydrofuran / 0.5 h / 20 °C 3.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C 3.2: sodium cyanoborohydride / tetrahydrofuran / 8 h / 0 - 20 °C 4.1: 99 percent / LiOH*H2O / tetrahydrofuran; H2O / 9 h / 20 °C 5.1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr 6.1: potassium carbonate / tetrahydrofuran; H2O / 0 - 20 °C 7.1: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C View Scheme

1.1: HCl / tetrahydrofuran / 0.5 h / 20 °C 2.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C 2.2: sodium cyanoborohydride / tetrahydrofuran / 8 h / 0 - 20 °C 3.1: 99 percent / LiOH*H2O / tetrahydrofuran; H2O / 9 h / 20 °C 4.1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr 5.1: potassium carbonate / tetrahydrofuran; H2O / 0 - 20 °C 6.1: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C View Scheme

1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr 2: potassium carbonate / tetrahydrofuran; H2O / 0 - 20 °C 3: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C View Scheme

1: 99 percent / LiOH*H2O / tetrahydrofuran; H2O / 9 h / 20 °C 2: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr 3: potassium carbonate / tetrahydrofuran; H2O / 0 - 20 °C 4: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C View Scheme

1.1: 88 percent / p-toluenesulfonic acid / ethanol / 20 °C 2.1: 100 percent / hydrogen / [Rh(COD)Cl]2; (S)-(+)-DTBM-SEGPHOS / toluene / 96 h / 30 °C / 45600 Torr 3.1: HCl / tetrahydrofuran / 0.5 h / 20 °C 4.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C 4.2: sodium cyanoborohydride / tetrahydrofuran / 8 h / 0 - 20 °C 5.1: 99 percent / LiOH*H2O / tetrahydrofuran; H2O / 9 h / 20 °C 6.1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr 7.1: potassium carbonate / tetrahydrofuran; H2O / 0 - 20 °C 8.1: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C View Scheme

暂无反应条件数据

(electrolysis);

2: ethanol; NH3 3: palladium; methanol; acetic acid / Hydrogenation View Scheme

1: palladium/charcoal; acetic acid; aqueous methanol / Hydrogenation 2: HCl View Scheme