1-(7-硝基-9H-芴-2-基)-乙酮合成路线 （共 9 条）
反应条件
aluminium trichloride; nitrobenzene T=40 - 55°C;
参考文献
Oehlschlaeger; MacGregor
Journal of the American Chemical Society, 1949 , vol. 71, p. 3223
反应条件
1: acetic acid; HNO3 2: CrO3; acetic acid View Scheme
参考文献
Sawicki
Journal of the American Chemical Society, 1954 , vol. 76, p. 2269
反应条件
chromium(VI) oxide; acetic acid
参考文献
Sawicki
Journal of the American Chemical Society, 1954 , vol. 76, p. 2269
参考文献
Oehlschlaeger; MacGregor
Journal of the American Chemical Society, 1949 , vol. 71, p. 3223
反应条件
hydrogenchloride; 3-chloro-benzenecarboperoxoic acid 1.) CHCl3, 10 d, 2.) aq. EtOH, reflux, 3.5 h; Yield given. Multistep reaction;
参考文献
Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24
反应条件
1: 48 percent / 4-toluenesulfonic acid / benzene / 18 h / Heating
2: 1.) NH4Cl, Zn, 2.) NaHCO3 / 1.) DMF, 0 deg C, 1.5 h, 2.) Et2O, 0 deg C, 1 h
3: HCl / H2O / pH 4-5
View Scheme
参考文献
Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24
反应条件
1: 1.) 3-chloroperbenzoic acid, 2.) HCl / 1.) CHCl3, 10 d, 2.) aq. EtOH, reflux, 3.5 h
2: 50 percent / K2CO3 / acetone / 3 h / Heating
3: 1.) NH4Cl, Zn, 2.) NaHCO3 / 1.) DMF, 0 deg C, 1 h, 2.) Et2O, 0 deg C, 1 h
View Scheme
参考文献
Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24
反应条件
1: 1.) 3-chloroperbenzoic acid, 2.) HCl / 1.) CHCl3, 10 d, 2.) aq. EtOH, reflux, 3.5 h
2: 50 percent / K2CO3 / acetone / 3 h / Heating
View Scheme
参考文献
Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24
反应条件
(i) PhCO3H, (ii) aq. HCl, EtOH, (iii) /BRN= 635994/, K2CO3; Multistep reaction;
参考文献
Andrew,H.F. et al.
Journal of the Chemical Society [Section] C: Organic, 1968 , p. 1761 - 1764
