8-甲氧基-1,2,3,4-四氢异喹啉合成路线 （共 21 条）
反应条件
1: AcOH / ethanol / 18 h / Heating 2: NaBH4 / methanol / 1 h / Ambient temperature 3: 92 percent / acetic anhydride / 1 h / 70 °C 4: 95 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 4 h 6: 68 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 7: 90 percent / 10percent aq. NaOH / ethanol / 15 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 6 p. 918 - 927
反应条件
1: 92 percent / acetic anhydride / 1 h / 70 °C 2: 95 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 4 h 4: 68 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 90 percent / 10percent aq. NaOH / ethanol / 15 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 6 p. 918 - 927
反应条件
1: 68 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 90 percent / 10percent aq. NaOH / ethanol / 15 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 6 p. 918 - 927
反应条件
1: 95 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 4 h 3: 68 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 90 percent / 10percent aq. NaOH / ethanol / 15 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 6 p. 918 - 927
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 4 h 2: 68 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 90 percent / 10percent aq. NaOH / ethanol / 15 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 6 p. 918 - 927
反应条件
trifluoroacetic acid 15 h; Heating; Title compound not separated from byproducts.;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 5 p. 2499 - 2512
反应条件
hydrogen bromide T=120°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
boron tribromide in dichloromethane T=-78°C; 3.5 h;
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
反应条件
palladium on activated charcoal in 1,3,5-trimethyl-benzene T=190 - 200°C; 0.5 h;
参考文献
Shanker, P. Sathya; Rao, G. S. R. Subba
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 12 p. 1209 - 1213
反应条件
manganese(IV) oxide in dichloromethane T=23°C; 40 h; Title compound not separated from byproducts;
参考文献
Kashdan, David S.; Schwartz, John A.; Rapoport, Henry
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2638 - 2643
