8-甲氧基-1,2,3,4-四氢异喹啉合成路线 （共 21 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Sall; Grunewald
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2208 - 2216
反应条件
sodium hydroxide in ethanol 15 h; Heating;
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) from -78 deg C to RT 2: 94 percent / ethyl chloroformate / CHCl3 / 0.25 h / 0 °C 3: 88 percent / dimethylformamide / 4 h 4: concd H2SO4, H2 / PtO2 / ethanol / 12 h / 2585.7 Torr 5: benzene / 3 h / Heating 6: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2638 - 2643
反应条件
1: concd H2SO4, H2 / PtO2 / ethanol / 12 h / 2585.7 Torr 2: benzene / 3 h / Heating 3: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2638 - 2643
反应条件
1: 94 percent / ethyl chloroformate / CHCl3 / 0.25 h / 0 °C 2: 88 percent / dimethylformamide / 4 h 3: concd H2SO4, H2 / PtO2 / ethanol / 12 h / 2585.7 Torr 4: benzene / 3 h / Heating 5: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2638 - 2643
反应条件
1: 88 percent / dimethylformamide / 4 h 2: concd H2SO4, H2 / PtO2 / ethanol / 12 h / 2585.7 Torr 3: benzene / 3 h / Heating 4: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2638 - 2643
反应条件
1: 13 percent / PPA / 140 °C 2: LAH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1885 - 1888
反应条件
1: Et3N / tetrahydrofuran 2: 13 percent / PPA / 140 °C 3: LAH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1885 - 1888
反应条件
hydrogenchloride T=20°C; Pictet-Spengler cyclization; pH=0.4; 24 h;
参考文献
Ben-Daniel; Deuther-Conrad; Scheunemann; Steinbach; Brust; Mishani
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 12 p. 6364 - 6370
反应条件
1: benzene / 3 h / Heating 2: 93 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2638 - 2643
