5-(6-氨基嘌呤-9-基)-2-(羟基甲基)四氢呋喃-3-醇合成路线 （共 15 条）
反应条件
hydrogen; potassium carbonate; palladium on activated charcoal in ethanol P=2585.7 Torr; 20 h;
参考文献
Kazimierczuk, Zygmunt; Vilpo, Juhani; Hildebrand, Catherine; Wright, George
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1683 - 1687
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.75 h;
参考文献
Gulyaeva, Irma V.; Neuvonen, Kari; Loennberg, Harri; Rodionov, Andrei A.; Shcheveleva, Elena V.; Bobkov, Georgii V.; Efimtseva, Ekaterina V.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 12 p. 1849 - 1864
反应条件
1: 45 percent / methanolic ammonia / 32 h / 65 °C 2: 92 percent / H2, potassium carbonate / 10percent Pd/C / ethanol / 20 h / 2585.7 Torr View Scheme
参考文献
Kazimierczuk, Zygmunt; Vilpo, Juhani; Hildebrand, Catherine; Wright, George
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1683 - 1687
参考文献
Baud; Chavis; Lucas; Imbach
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4437 - 4440
反应条件
hydrogenchloride; dichloromethane Behandeln des Reaktionsprodukts mit 6-Benzoylamino-purin-9-ylquecksilber-chlorid in DMSO und anschliessend mit methanol.Bariummethylat;
参考文献
Ness; Fletcher
Journal of the American Chemical Society, 1959 , vol. 81, p. 4752
反应条件
1: 95 percent / KI, dibenzo-18-crown-6 / acetonitrile; toluene / Heating; time: 2 - 4h 2: 62 percent / NH3 / methanol View Scheme
参考文献
Baud; Chavis; Lucas; Imbach
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4437 - 4440
反应条件
1: 95 percent / KI, dibenzo-18-crown-6 / acetonitrile; toluene / Heating; time: 2 - 4h 2: 62 percent / NH3 / methanol View Scheme
参考文献
Baud; Chavis; Lucas; Imbach
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4437 - 4440
反应条件
1: 85 percent / pyridine / 25 h / 65 °C 2: 1) bis-trimethylsilylacetamide; 2) trimethylsilyl trifluoromethanesulfonate / 1) acetonitrile, 70 deg C, 15 min; 2) acetonitrile, 70 deg C, 4 h 3: ammonia / methanol / 12 h / 40 °C View Scheme
参考文献
Yamaguchi; Saneyoshi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1441 - 1450
反应条件
1: 1) bis-trimethylsilylacetamide; 2) trimethylsilyl trifluoromethanesulfonate / 1) acetonitrile, 70 deg C, 15 min; 2) acetonitrile, 70 deg C, 4 h 2: ammonia / methanol / 12 h / 40 °C View Scheme
参考文献
Yamaguchi; Saneyoshi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1441 - 1450
反应条件
1: ammonia / methanol / 72 h / 20 °C 2: 51 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.75 h / 20 °C View Scheme
参考文献
Gulyaeva, Irma V.; Neuvonen, Kari; Loennberg, Harri; Rodionov, Andrei A.; Shcheveleva, Elena V.; Bobkov, Georgii V.; Efimtseva, Ekaterina V.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 12 p. 1849 - 1864
