(3R)-3-甲基-2-苯并呋喃-1(3H)-酮合成路线 （共 20 条）
反应条件
4 A molecular sieve; pyridinium chlorochromate in dichloromethane T=20°C; 1.5 h;
参考文献
Hayashi; Hirate; Kitayama; Tsuji; Torii; Uozumi
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1441 - 1449
反应条件
1: D-glucose / water / 21 h 2: hydrogenchloride; water / 48 h / 20 °C View Scheme
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
反应条件
1.1: hydrogenchloride; acetic acid / water / 0.08 h / Reflux 1.2: 2 h / 0 - 20 °C 2.1: D-glucose / water / 21 h 3.1: hydrogenchloride; water / 48 h / 20 °C View Scheme
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
反应条件
1.1: O3 / CH2Cl2 / 1 h / -78 °C 1.2: Zn; AcOH / CH2Cl2 / 2 h / 0 °C 2.1: 26.0 mg / PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Hayashi; Hirate; Kitayama; Tsuji; Torii; Uozumi
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1441 - 1449
反应条件
1.1: 265 mg / PdCl2(MeCN)2 / benzene / 0.08 h / Heating 2.1: O3 / CH2Cl2 / 1 h / -78 °C 2.2: Zn; AcOH / CH2Cl2 / 2 h / 0 °C 3.1: 26.0 mg / PCC; 4 Angstroem molecular sieves / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Hayashi; Hirate; Kitayama; Tsuji; Torii; Uozumi
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1441 - 1449
反应条件
1: 1.) sec-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to 25 deg C, 8h 2: 80 percent / Pseudomonas putida ATCC 12633, o-toluic acid / H2O / 72 h / 30 °C View Scheme
参考文献
Kitayama, Takashi
Tetrahedron Asymmetry, 1997 , vol. 8, # 22 p. 3765 - 3774
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium isopropoxide; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-p-tolylsulphonamide T=20°C; 18 h; Product distribution; Further Variations:ReagentsTemperaturesreaction times;
参考文献
Everaere, Kathelyne; Mortreux, Andre; Bulliard, Michel; Brussee, Johannes; Van Der Gen, Arne; Nowogrocki, Guy; Carpentier, Jean-Francois
European Journal of Organic Chemistry, 2001 , # 2 p. 275 - 291
反应条件
1: 53 percent / 97percent H2SO4 / 1 h / Heating 2: 92 percent / Geotrichum candidum IFO34614, H20 / 24 h / 30 °C View Scheme
参考文献
Kitayama, Takashi
Tetrahedron Asymmetry, 1997 , vol. 8, # 22 p. 3765 - 3774
反应条件
pyridinium chlorochromate 0.5 h; Ambient temperature; Yield given;
参考文献
Takahashi; Tsubuki; Higashiyama
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3136 - 3169
反应条件
diisobutylaluminium hydride; magnesium bromide 1.) a.) CH2Cl2, RT, 1 h, b.) -78 deg C, 1 h, 2.) toluene, -78 deg C; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tamai, Yasufumi; Koike, Shinji; Ogura, Atsuhiko; Miyano, Sotaro
Journal of the Chemical Society, Chemical Communications, 1991 , # 12 p. 799 - 800
