9-beta-D-呋喃阿拉伯糖基-2,6-二氨基嘌呤合成路线 （共 16 条）
反应条件
ammonia in methanol T=100°C; 8 h; sealed tube;
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
ammonia in methanol T=100°C; 10 h; sealed tube;
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
Citrobacter koseri in aq. phosphate buffer T=60°C; pH=7; 24 h; Microbiological reaction; Reagent/catalyst;
参考文献
Nobile, Matias; Medici, Rosario; Terreni, Marco; Lewkowicz, Elizabeth S.; Iribarren, Adolfo M.
Process Biochemistry, 2012 , vol. 47, # 12 p. 2182 - 2188
反应条件
Enterobacter gergoviae T=60°C; pH=7; 48 h; aq. phosphate bufferMicrobiological reaction;
参考文献
Medici, Rosario; Iribarren, Adolfo M.; Lewkowicz, Elizabeth S.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4210 - 4212
反应条件
1: 2 M KOH / H2O / 0.33 h / Ambient temperature; pH=10.3 2: cytidine deaminase ( EC 3.5.4.5 ) / 48 h / 37 °C / pH=6.8 with acetic acid 3: K2HPO4, sodium azide / purine nucleoside phodphorylase ( EC 2.4.2.1 ), uridine phosphorylase ( EC 2.4.2.3 ) / 288 h / 37 °C / pH=7.1 View Scheme
参考文献
Krenitski, Thomas A.; Koszalka, George, W.; Tuttle, Joel V.; Rideout, Janet L.; Elion, Gertrude B.
Carbohydrate Research, 1981 , vol. 97, p. 139 - 146
反应条件
1: 40 percent CH3NH2 / 2 h / 0 - 5 °C 2: 70 percent / pyridine / 20 h / Ambient temperature 3: 62 percent / dry H2S / pyridine / 15 h / 12 °C / sealed tube 4: 75 percent / Raney Ni / ethanol; H2O / 0.5 h / Heating 5: 67 percent / NH3 (g) / methanol / 10 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
1: 95 percent / acetic acid; acetic anhydride / 0.5 h / Heating 2: 40 percent CH3NH2 / 2 h / 0 - 5 °C 3: 70 percent / pyridine / 20 h / Ambient temperature 4: 62 percent / dry H2S / pyridine / 15 h / 12 °C / sealed tube 5: 75 percent / Raney Ni / ethanol; H2O / 0.5 h / Heating 6: 67 percent / NH3 (g) / methanol / 10 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
1: cytidine deaminase ( EC 3.5.4.5 ) / 48 h / 37 °C / pH=6.8 with acetic acid 2: K2HPO4, sodium azide / purine nucleoside phodphorylase ( EC 2.4.2.1 ), uridine phosphorylase ( EC 2.4.2.3 ) / 288 h / 37 °C / pH=7.1 View Scheme
参考文献
Krenitski, Thomas A.; Koszalka, George, W.; Tuttle, Joel V.; Rideout, Janet L.; Elion, Gertrude B.
Carbohydrate Research, 1981 , vol. 97, p. 139 - 146
反应条件
1: 87 percent / pyridine / 40 h / Ambient temperature 2: phosphoryl chloride, N,N-diethylaniline / 0.08 h / Heating 3: 78 percent / NH3 (g) / methanol / 8 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
反应条件
1: 70 percent / pyridine / 20 h / Ambient temperature 2: 62 percent / dry H2S / pyridine / 15 h / 12 °C / sealed tube 3: 75 percent / Raney Ni / ethanol; H2O / 0.5 h / Heating 4: 67 percent / NH3 (g) / methanol / 10 h / 100 °C / sealed tube View Scheme
参考文献
Muraoka; Iwahara; Kaneko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 6 p. 2609 - 2613
