反应条件
1: 82 percent / PBr3, pyridine / diethyl ether / 1) rt, overnight, 2) reflux, 2 h
2: 1) Mg / 3) Li2CuCl4 / 1) THF, 2) THF, -10 deg C, 30 min, 3) a) 0 to -10 deg C, 6 h, b) rt, overnight
3: p-toluenesulphonic acid / methanol / 3 h / Heating
4: 68 percent / pyridine / 24 h / Ambient temperature
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Sabharwal, Arun; Vohra, Neelam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1042 - 1044
