2-甲氧基-N-甲基苯甲酰胺合成路线 （共 12 条）
反应条件
tris(2,4-di-tert-butyl-phenyl) phosphite; sodium methylate; [Ni(O2CCH3)2]*4H2O in diethylene glycol dimethyl ether T=110°C; 10 h;
参考文献
Jo, Youngshin; Ju, Jinhun; Choe, Jaehoon; Kwang, Ho Song; Lee, Sunwoo
Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6358 - 6361
参考文献
Kuhn, Bernd; Mohr, Peter; Stahl, Martin
Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2601 - 2611
参考文献
Merck and Co., Inc.
Patent: WO2003/104207 A2, 2003 ;
Location in patent: Page 54 ;
反应条件
thionyl chloride 2) H2O, 0 deg C; Multistep reaction;
参考文献
Brahmbhatt
Journal of the Indian Chemical Society, 1989 , vol. 66, # 7 p. 481 - 482
参考文献
Faust et al.
Journal of the American Pharmaceutical Association (1912-1977), 1956 , vol. 45, p. 514,517
反应条件
dichloro-acetic acid in acetonitrile Irradiationother nitrones; kinetic data of DCA fluorescence quenching, ΔG of the single electron transfer to 1DCA*; MechanismThermodynamic data;
参考文献
Iwano, Yasunori; Kawamura, Yasuhiko; Miyoshi, Hiroki; Yoshinari, Toshifumi; Horie, Tokunaru
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 8 p. 2348 - 2350
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran
参考文献
Hoechst Marion Roussel, Inc.
Patent: US5672602 A1, 1997 ;
US 5672602 A
Title/Abstract Full Text Show Details
Merrell Pharmaceuticals Inc.
Patent: US5597845 A1, 1997 ;
反应条件
piperazine in N,N-dimethyl acetamide
T=150°C; Substitution; Demethylation; 13 h;
参考文献
Nishioka, Hiroyasu; Nagasawa, Masaaki; Yoshida, Kiyoshi
Synthesis, 2000 , # 2 p. 243 - 246
反应条件
1: 2-methoxy-N-methylbenzamide With n-butyllithium
T=0°C;
2: N,N-dimethyl-formamide
参考文献
Luethy, Christoph; Zondler, Helmut; Rapold, Thomas; Seifert, Gottfried; Urwyler, Bernhard; Heinis, Thomas; Steinruecken, Hans Christian; Allen, James
Pest Management Science, 2001 , vol. 57, # 3 p. 205 - 224
反应条件
1: 1.) n-BuLi, tetramethylethylenediamine (TMEDA) / 1.) ether, THF, 0 deg C, 30 min, 2.) ether, THF, RT, 24 h
2: 84 percent / 3 N aq. HCl / 7 h / Heating
View Scheme
参考文献
Yeola, Suresh N.; Mali, R. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 804 - 806
