3-(4-氟苯巯基)-2-羟基-2-甲基丙酸合成路线 (共 6 条)
反应条件
hydrogenchloride in methanol; ethyl acetate
参考文献
Dolitzky, Ben-Zion; Reany, Ofer; Shammai, Jenny
Patent: US2003/45741 A1, 2003 ;
反应条件
1: 4-fluorophenyl mercaptan With sodium methylate in methanol 0.25 h; 2: methyl 2-methyl-2-oxiranecarboxylate in toluene T=20 - 60°C; 3 h; 3: With hydrogenchloride; sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
参考文献
Cosma S.p.A.
Patent: EP1614677 A2, 2006 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: With sodium hydroxide; water T=60°C; 0.5 - 2 h; 2: With hydrogenchloride in water T=20 - 25°C; pH=2 - 2.5; 0.5 h; Product distribution / selectivity;
参考文献
EP1614677 A2, ;
Page/Page column 7-8 ;
反应条件
1: in toluene T=20 - 60°C; 3 h; 2: With sodium hydroxide; water in toluene T=10 - 20°C; 3: With hydrogenchloride in water pH=3; Product distribution / selectivity;
参考文献
US2006/41161 A1, ;
Page/Page column 3 ;
反应条件
thionyl chloride in DMA (dimethylacetamide); dichloromethane; ethyl acetate
参考文献
Nobex Corporation
Patent: US6583306 B1, 2003 ;
反应条件
in toluene
T=100°C; 5 h;
参考文献
Pizzatti, Enrica; Vigano, Enrico; Lussana, Massimiliano; Landonio, Ernesto
Patent: US2006/41161 A1, 2006 ;
Location in patent: Page/Page column 4 ;