叔丁氧羰基-脯氨酰-琥珀酰亚胺合成路线 （共 15 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; Esterification;
参考文献
Gudasheva; Zaitseva; Bondarenko; Shcherbakova; Asmakova; Rozantsev; Ostrovskaya; Voronina; Seredenin
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 11 p. 574 - 580
反应条件
pyridine T=22°C; 1 h;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 8 p. 1904 - 1907,1696 - 1698
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
1: Amberlyst® - 15 / ethanol / 40 - 45 °C 2: dicyclohexyl-carbodiimide / acetonitrile / 0.25 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 20, # 6 p. 1530 - 1538
反应条件
1: Amberlyst® - 15 / ethanol / 40 - 45 °C 2: dicyclohexyl-carbodiimide / acetonitrile / 0.25 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 20, # 6 p. 1530 - 1538
反应条件
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide 1.) CH2Cl2, -10 deg C, 1 h, 2.) -5 to 10 deg C, 1 h; room temperature, overnight; Yield given. Multistep reaction;
参考文献
Silhankova, Alexandra; Sindelar, Karel; Dobrovsky, Karel; Krejci, Ivan; Hodkova, Jarmila; Polivka, Zdenek
Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, # 7 p. 1085 - 1092
反应条件
ammonia in chloroform Ambient temperature;
参考文献
Synthetic Communications, , vol. 24, # 9 p. 1239 - 1246
反应条件
1: 29 percent / NH3(gas) / CHCl3 / Ambient temperature 2: HCl / dioxane View Scheme
参考文献
Yonezawa; Jingu; Katakai
Synthetic Communications, 1994 , vol. 24, # 9 p. 1239 - 1246
反应条件
1: 1.) dioxane, water, 20 deg C, 3 h, 2.) DMF, 20 deg C, 3 h 2: 77 percent / 2.3 N aq. HCl / ethyl acetate / 0.67 h View Scheme
参考文献
Golubovich, V. P.; Martinovich, V. P.; Usenko, A. B.; Slobodchikova, L. K.; Titov, S. A.; Ashmarin, I. P.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 440 - 444
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 675 - 679
