Boc-L-亮氨酸N-羟基琥珀酰亚胺脂合成路线 （共 14 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 4°C;
参考文献
DeGraw, Joseph I.; Almquist, Ronald G.; Hiebert, Charles K.; Colwell, William T.; Crase, Jac; Hayano, Takeshi; Judd, Amrit K.; Dousman, Linda; Smith, R. Lane; Waud, William R.; Uchida, Itsuo
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2386 - 2397
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
反应条件
1: 96 percent / Et3N / 18 h / 20 °C 2: TFA; acetone 3: 95 percent / Et3N / 18 h / 20 °C 4: aq. HCl; acetone / dioxane 5: 95 percent / HCOONa; Ac2O / 1.33 h / 0 - 20 °C 6: 95 percent / aq. NaOH / methanol / 0.33 h / 20 °C View Scheme
参考文献
Martinez; Laur
Synthesis, 1982 , vol. No. 11, p. 979 - 981
反应条件
triethylamine in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , vol. 1996, # 12 p. 2701 - 2706
反应条件
anhydrous sodium hydrogen carbonate in 1,4-dioxane; water
反应条件
sodium tetrahydroborate; acetic acid in 1,4-dioxane; methanol
参考文献
Sergeev, Maxim E.; Pronin, Victor B.; Voyushina, Tatiana L.
Synlett, 2005 , # 18 art. no. G24405ST, p. 2802 - 2804
反应条件
triethylamine in dichloromethane
参考文献
Tetrahedron Letters, , vol. 45, # 3 p. 501 - 504
反应条件
triethylamine in ethylene glycol dimethyl ether 18 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2852 - 2857
反应条件
2: 4 M HCl / dioxane View Scheme
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418
反应条件
triethylamine in dichloromethane
参考文献
Postnikova, Brenda J.; Anslyn, Eric V.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 501 - 504
