Boc-L-丙氨酸 N-丁二酰亚胺酯合成路线 （共 17 条）
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane Ambient temperature;
参考文献
Laakso; Stjarnkvist; Sjoholm
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 2 p. 134 - 140
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Societe Nationale des Poudres et Explosifs
Patent: US4782164 A1, 1988 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in 1,4-dioxane T=20°C;
参考文献
Lioux, Thierry; Busson, Roger; Rozenski, Jef; Nguyen-Disteche, Martine; Frere, Jean-Marie; Herdewijn, Piet
Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 10 p. 1615 - 1641
反应条件
N,N-dicyclohexylamine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
参考文献
Pastuszak, Jacek; Gardner, Joseph H.; Singh, Jasbir; Rich, Daniel H.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2982 - 2987
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
1: 69 percent / triethylamine / dioxane / Ambient temperature 2: 59 percent / 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide (DAEC) / propan-2-ol / Ambient temperature View Scheme
参考文献
Carbohydrate Research, , vol. 132, p. 275 - 286
反应条件
1: magnesium / methanol / 4 h / 20 °C 2: dicyclohexyl-carbodiimide / 1,4-dioxane / 0 - 20 °C View Scheme
参考文献
Synlett, , # 1 art. no. W17911ST, p. 142 - 144
反应条件
1: L-proline With tetra(n-butyl)ammonium hydroxide; potassium carbonate in 1,4-dioxane 0.25 h; 2: N-tert-butoxycarbonyl-L-alanine-N-hydroxysuccinimide ester in 1,4-dioxane 10 h;
参考文献
WO2014/54980 A1, ;
Page/Page column 5; 6 ;
