N-(苯基甲氧基羰基)-L-异亮氨酸 2,5-二氧代-1-吡咯烷基酯合成路线 （共 7 条）
反应条件
1: N-CBZ-L-isoleucine With bis(trichloromethyl) carbonate; triethylamine in dichloromethane T=0°C; 2: 1-hydroxy-pyrrolidine-2,5-dione in dichloromethane T=20°C; 0.5 h;
参考文献
Kim, Misoo; Han, Ki-Jong
Synthetic Communications, 2009 , vol. 39, # 24 p. 4467 - 4472
反应条件
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 5 h;
参考文献
Soft Matter, , vol. 7, # 5 p. 2121 - 2126
反应条件
pyridine in acetonitrile
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5559 - 5562
反应条件
ammonium hydroxide in tetrahydrofuran
参考文献
Nokihara, K.; Yanaihara, C.; Iguchi, K.; Fukata, S.; Tanaka, M.; et al.
Journal of the American Chemical Society, 1984 , vol. 106, # 25 p. 7909 - 7916
反应条件
sodium hydrogencarbonate in ethanol
Ambient temperature;
参考文献
Sakurai,A.; Okumura,Y.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 540 - 543
反应条件
1: 81 percent / Et3N / dioxane; H2O / 20 h / Ambient temperature
2: 89 percent / H2 / Pd black / acetic acid; methanol / 72 h / Ambient temperature
View Scheme
参考文献
Otagiri, Ken; Miyake, Ichizo; Ishibashi, Norio; Fukui, Hiroshi; Kanehisa, Hidenori; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 4 p. 1116 - 1119
反应条件
triethylamine in 1,4-dioxane; water
20 h; Ambient temperature;
参考文献
Otagiri, Ken; Miyake, Ichizo; Ishibashi, Norio; Fukui, Hiroshi; Kanehisa, Hidenori; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 4 p. 1116 - 1119
