5-甲氧基-3,4-二氢-2H-1-萘酮合成路线 （共 55 条）
反应条件
in diethyl ether
0.5 h; Heating;
参考文献
Hacksell; Johansson; Arvidsson; Nilsson; Hjorth; Carlsson; Wikstroem; Sanchez; Lindberg
Journal of medicinal chemistry, 1984 , vol. 27, # 8 p. 1003 - 1007
反应条件
1: diethyl ether / 3 h / Heating
2: 1.9 g / aq. HCl; ZnCl2 / benzene / 5 h
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
参考文献
Banerjee, Ajoy K.; Melean, Carlos E.; Mora, Henry D.; Cabrera, Elvia V.; Laya, Manuel S.
Journal of Chemical Research, 2007 , # 2 p. 109 - 111
反应条件
1.1: various solvent(s)
2.1: p-TSA / toluene
3.1: monoisopropylcamphenylborane / tetrahydrofuran / -20 - -16 °C
3.2: NaOH; 30 percent aq. H2O2
4.1: pyridine
5.1: NaN3 / H2O; dimethylformamide
6.1: LAH / tetrahydrofuran
7.1: Et3N
8.1: LAH / tetrahydrofuran
9.1: Et3N
10.1: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: diethyl ether / Erhitzen des Reaktionsprodukts mit KHSO4 auf 130grad
2: peroxybenzoic acid
View Scheme
参考文献
Howell; Taylor
Journal of the Chemical Society, 1958 , p. 1248,1251
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane
T=0°C; 2 h;
2: With water; NAF in hexane; dichloromethane
2 h; Product distribution / selectivity;
参考文献
Szewczyk, Jerzy Ryszard; Donaldson, Kelly H.
Patent: US2006/3991 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
US 20060003991 A1
反应条件
toluene-4-sulfonic acid; 3-hydroxy-2,2-dimethylpropanol in toluene
48 h; Reflux;
参考文献
Imai, Masao; Morais, Goreti Ribeiro; Al-Hindawi, Bassam; Al-Sulaibi, Mazen A.M.; Meetani, Mohammad; Thiemann, Thies
Journal of Chemical Research, 2010 , # 6 p. 325 - 329
反应条件
selenium(IV) oxide in acetic acid
T=60°C; 4 h;
参考文献
Bekaert, Alain; Andrieux, Jean; Plat, Michel; Brion, Jean-Daniel
Tetrahedron Letters, 1997 , vol. 38, # 24 p. 4219 - 4220
反应条件
1: diethyl ether; benzene / Erhitzen des Reaktionsprodukts unter vermindertem Druck
2: selenium / 280 °C
View Scheme
参考文献
Henderson,W.A. et al.
Journal of the American Chemical Society, 1969 , vol. 91, # 22 p. 6049 - 6057
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 14 h;
参考文献
Geiseler, Oliver; Mueller, Monika; Podlech, Joachim
Tetrahedron, 2013 , vol. 69, # 18 p. 3683 - 3689
