2-(2-溴乙基)-1,3-二氧杂环己烷合成路线 （共 18 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran
参考文献
Thomas, James A.; Heathock, Clayton H.
Tetrahedron Letters, 1980 , vol. 21, p. 3235 - 3236
反应条件
1: 1-(1,3-dioxan-2-yl)-2-bromoethane With iodine; magnesium in tetrahydrofuran
T=65°C;
2: benzyl {4-[methoxy(methyl)amino]-4-oxobutyl}methylcarbamate in tetrahydrofuran
T=4 - 65°C; 2 h;
参考文献
Ashcroft, Christopher P.; Pettman, Alan; Watkinson, Simon; Hellier, Paul
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 98 - 103
反应条件
1: 70 percent / TEBA / H2O; CCl4 / 120 h / Heating
2: 95 percent / LiAlH4 / diethyl ether / -20 °C
3: 50 percent / PDC / CH2Cl2 / 24 h / 25 °C
View Scheme
参考文献
Bertrand, M.; Leandri, G.; Meou, A.
Tetrahedron, 1981 , vol. 37, p. 1703 - 1710
反应条件
1: 70 percent / TEBA / H2O; CCl4 / 120 h / Heating
2: 95 percent / LiAlH4 / diethyl ether / -20 °C
View Scheme
参考文献
Bertrand, M.; Leandri, G.; Meou, A.
Tetrahedron, 1981 , vol. 37, p. 1703 - 1710
反应条件
N,N,N',N,-tetramethylethylenediamine; ((Me)N2N)Ni-Cl in tetrahydrofuran
T=20°C; Kumada-Corriu-Tamao coupling reaction; 2 h; Inert atmosphere;
参考文献
Vechorkin, Oleg; Proust, Valerie; Hu, Xile
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766
反应条件
1,1-dimethylpropan-1-ol; ((Me)N2N)Ni-Cl; sodium iodide; sodium hydroxide in 1,4-dioxane
T=80°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere;
参考文献
Di Franco, Thomas; Boutin, Nicolas; Hu, Xile
Synthesis (Germany), 2013 , vol. 45, # 21 art. no. SS-2013-Z0609-FA, p. 2949 - 2958
反应条件
hydroquinone in tetrahydrofuran
参考文献
Korea Advanced Institute of Science and Technology
Patent: US6465671 B1, 2002 ;
反应条件
((Me)N2N)Ni-Cl in tetrahydrofuran; isobutyramide
T=-35 - 20°C; Inert atmosphere;
参考文献
Vechorkin, Oleg; Hu, Xile
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 2937 - 2940
Angewandte Chemie, 2009 , vol. 121, p. 2981 - 2984
